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A Eukaryote without a Mitochondrial Organelle
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SYSNO ASEP 0486310 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title A Eukaryote without a Mitochondrial Organelle Author(s) Karnkowska, A. (CA)
Vacek, V. (CZ)
Zubáčová, Z. (CZ)
Treitli, S.C. (CZ)
Petrzelkova, R. (CZ)
Eme, L. (CA)
Novák, L. (CZ)
Žárský, V. (CZ)
Barlow, L.D. (CA)
Herman, E.K. (CA)
Soukal, P. (CZ)
Hroudová, Miluše (UMG-J) RID
Doležal, P. (CZ)
Stairs, C.W. (CA)
Roger, A. J. (CA)
Eliaš, M. (CZ)
Dacks, J.B. (CA)
Vlček, Čestmír (UMG-J) RID
Hampl, V. (CZ)Number of authors 19 Source Title Current Biology. - : Cell Press - ISSN 0960-9822
Roč. 26, č. 10 (2016), s. 1274-1284Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords arginine dihydrolase pathway ; tail-anchored proteins ; fe-s cluster ; trichomonas-vaginalis ; entamoeba-histolytica ; giardia-intestinalis ; tritrichomonas-fetus ; genome annotation ; energy-metabolism ; gene-transfer Subject RIV EB - Genetics ; Molecular Biology OECD category Developmental biology R&D Projects LQ1604 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GAP506/12/1010 GA ČR - Czech Science Foundation (CSF) Institutional support UMG-J - RVO:68378050 UT WOS 000376466000022 DOI 10.1016/j.cub.2016.03.053 Annotation The presence of mitochondria and related organelles in every studied eukaryote supports the view that mitochondria are essential cellular components. Here, we report the genome sequence of a microbial eukaryote, the oxymonad Monocercomonoides sp., which revealed that this organism lacks all hallmark mitochondrial proteins. Crucially, the mitochondrial iron-sulfur cluster assembly pathway, thought to be conserved in virtually all eukaryotic cells, has been replaced by a cytosolic sulfur mobilization system (SUF) acquired by lateral gene transfer from bacteria. In the context of eukaryotic phylogeny, our data suggest that Monocercomonoides is not primitively amitochondrial but has lost the mitochondrion secondarily. This is the first example of a eukaryote lacking any form of a mitochondrion, demonstrating that this organelle is not absolutely essential for the viability of a eukaryotic cell. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2018
Number of the records: 1