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Warburg effect—damping of electromagnetic oscillations

SYSNO ASEP	0483569
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Warburg effect—damping of electromagnetic oscillations
Author(s)	Pokorný, Jiří (FZU-D) Pokorný, Jan (FZU-D)_{RID, ORCID} Borodavka, Fedir (FZU-D)_{RID, ORCID}
Number of authors	3
Source Title	Electromagnetic Biology and Medicine - ISSN 1536-8378 Roč. 36, č. 3 (2017), s. 270-278
Number of pages	9 s.
Language	eng - English
Country	US - United States
Keywords	Warburg effect ; mitochondrial dysfunction ; water ordering ; mitochondrial membrane potential ; biological electromagnetic activity ; cancer
Subject RIV	BO - Biophysics
OECD category	Biophysics
R&D Projects	GA16-12757S GA ČR - Czech Science Foundation (CSF)
Institutional support	FZU-D - RVO:68378271
UT WOS	000411461500006
EID SCOPUS	85020223825
DOI	10.1080/15368378.2017.1326933
Annotation	Mitochondrial dysfunction is a central defect in cells creating the Warburg and reverse Warburg effect cancers. Lowering of the inner membrane potential and shifting of the working point of mitochondria to high values of pH causes reorganization of the ordered water layer at the mitochondrial membrane. The reorganized ordered water layers at high pH values release electrons which are transferred to the cytosol rim of the layer. The electrons damp electromagnetic activity of Warburg effect cancer cells or fibroblasts associated with reverse Warburg effect cancer cells leading to lowered electromagnetic activity, disturbed coherence, increased oscillation frequencies and decreased level of biological functions. In reverse Warburg effect cancers, associated fibroblasts supply energy-rich metabolites to the cancer cell resulting in increased power of electromagnetic field, fluctuations due to shift of oscillations to an unstable nonlinear region, decreased frequency and loss of coherence.
Workplace	Institute of Physics
Contact	Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579
Year of Publishing	2018

Number of the records: 1