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/GD-Tracker/ A software for blood-brain barrier permeability assessment

SYSNO ASEP	0482636
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve SCOPUS
Title	/GD-Tracker/ A software for blood-brain barrier permeability assessment
Author(s)	Kala, David (FGU-C) Svoboda, Jan (FGU-C) Litvinec, Andrej (FGU-C) Pošusta, Antonín (FGU-C)_RID Lisý, J. (CZ) Šulc, V. (CZ) Tomek, A. (CZ) Marusič, P. (CZ) Jiruška, Přemysl (FGU-C)_{RID, ORCID, SAI} Otáhal, Jakub (FGU-C)_{RID, ORCID, SAI}
Source Title	Lékař a technika. Biomedicinské inženýrství a informatika. - : Česká lékařská společnost J. E. Purkyně - ISSN 0301-5491 Roč. 47, č. 2 (2017), s. 43-48
Number of pages	6 s.
Language	eng - English
Country	CZ - Czech Republic
Keywords	blood-brain barrier ; MRI ; Gd-DTPA ; permeability ; stroke ; epileptogenesis ; MATLAB ; freeware ; Gd-Tracker
Subject RIV	FH - Neurology
OECD category	Neurosciences (including psychophysiology
R&D Projects	NV15-33115A GA MZd - Ministry of Health (MZ)
	LM2015062 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	FGU-C - RVO:67985823
EID SCOPUS	85027324258
Annotation	Epilepsy is chronic neurological disease characterized by occurrence of spontaneous recurrent seizures affecting approximately 1% of people. One of the most common causes of epilepsy in adults is a stroke. The precise mechanism of development of vascular epilepsy is not known, and thus no reliable biomarker of postischemic epileptogenesis currently exists. Blood-brain barrier (BBB) impairment is phenomenon observed in several pathologies including stroke after which epilepsy often develops. Blood components such as albumin or thrombin have been experimentally shown to possess the capacity to increase excitability which results in seizures and epileptogenesis. We hypothesize that severity of the BBB breakdown during first weeks after the stroke can be used as a biomarker of postischemic epileptogenesis. This paper describes free MATLAB based software /Gd-Tracker/ and methodology developed for assessment of BBB permeability from magnetic resonance (MR) scans based on statistical voxel to voxel comparison of sequences with and without Gd-DTPA contrast. This software allows to evaluate extent and magnitude of impaired BBB region and thus serve as a tool for visualization and quantification of BBB breakdown.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2018

Number of the records: 1