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Amino-functionalized nanoparticles as a platform for mTOR activity modulation in hepatocellular carcinoma Huh7 cell line
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SYSNO ASEP 0480968 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title Amino-functionalized nanoparticles as a platform for mTOR activity modulation in hepatocellular carcinoma Huh7 cell line Author(s) Lunova, M. (CZ)
Zablotskyy, Vitaliy A. (FZU-D) RID
Prokhorov, Andriy (FZU-D) ORCID
Jirsa, M. (CZ)
Hof, Martin (UFCH-W) RID, ORCID
Olžyńska, Agnieszka (UFCH-W) RID
Jurkiewicz, Piotr (UFCH-W) RID, ORCID
Kubinová, Šárka (FZU-D) RID, ORCID
Lunov, Oleg (FZU-D) ORCID
Dejneka, Alexandr (FZU-D) RID, ORCIDNumber of authors 10 Source Title Journal of Hepatology. - : Elsevier - ISSN 0168-8278
Roč. 66, č. 1 (2017), s. 645-646Number of pages 2 s. Language eng - English Country NL - Netherlands Keywords nanoparticles ; cancer Subject RIV BO - Biophysics OECD category Biophysics R&D Projects Fellowship J. E. Purkyně GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) Institutional support FZU-D - RVO:68378271 ; UFCH-W - RVO:61388955 DOI 10.1016/S0168-8278(17)31749-X Annotation Nanoparticles are gaining increase of attention as a novel class of therapeutics for cancer [1]. The liver has been recognized as a highly promising organ for nanocarrierbased targeting [2].We have previously shown that polar groups (e.g. amino or carboxyl groups) modify the cellular uptake of nanoparticles and one can use such functionalization for efficient tumour targeting [3]. Here, we show that surface functionalization and stability of the nanoparticle core can be used for selective triggering of various biological effects in hepatocellular carcinoma cells (HuH7).
Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2018
Number of the records: 1