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Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory

SYSNO ASEP	0480564
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory
Author(s)	Foscarin, S. (GB) Raha-Chowdhury, R. (GB) Fawcett, James (UEM-P)_ORCID Kwok, Jessica (UEM-P)_{ORCID, RID}
Source Title	Aging. - : Impact Journals LLC - ISSN 1945-4589 Roč. 9, č. 6 (2017), s. 1607-1622
Number of pages	16 s.
Language	eng - English
Country	US - United States
Keywords	aging ; perineuronal net ; plasticity ; glycosaminoglycans
Subject RIV	FH - Neurology
OECD category	Neurosciences (including psychophysiology
R&D Projects	EF15_003/0000419 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	UEM-P - RVO:68378041
UT WOS	000405132500010
EID SCOPUS	85021702169
DOI	10.18632/aging.101256
Annotation	Chondroitin sulfate (CS) proteoglycans in perineuronal nets (PNNs) from the central nervous system (CNS) are involved in the control of plasticity and memory. Removing PNNs reactivates plasticity and restores memory in models of Alzheimer's disease and ageing. Their actions depend on the glycosaminoglycan (GAG) chains of CS proteoglycans, which are mainly sulfated in the 4 (C4S) or 6 (C6S) positions. While C4S is inhibitory, C6S is more permissive to axon growth, regeneration and plasticity. C6S decreases during critical period closure. We asked whether there is a late change in CS-GAG sulfation associated with memory loss in aged rats. Immunohistochemistry revealed a progressive increase in C4S and decrease in C6S from 3 to 18 months. GAGs extracted from brain PNNs showed a large reduction in C6S at 12 and 18 months, increasing the C4S/C6S ratio. There was no significant change in mRNA levels of the chondroitin sulfotransferases. PNN GAGs were more inhibitory to axon growth than those from the diffuse extracellular matrix. The 18-month PNN GAGs were more inhibitory than 3-month PNN GAGs. We suggest that the change in PNN GAG sulfation in aged brains renders the PNNs more inhibitory, which lead to a decrease in plasticity and adversely affect memory.
Workplace	Institute of Experimental Medicine
Contact	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Year of Publishing	2018

Number of the records: 1