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Lambda phage genetic switch as a system with critical behaviour

SYSNO ASEP	0479051
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Lambda phage genetic switch as a system with critical behaviour
Author(s)	Vohradský, Jiří (MBU-M)_{RID, ORCID}
Source Title	Journal of Theoretical Biology. - : Elsevier - ISSN 0022-5193 Roč. 431, OCT 27 2017 (2017), s. 32-38
Number of pages	7 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	Critical behaviour ; Phage lambda ; Genetic networks
Subject RIV	EE - Microbiology, Virology
OECD category	Microbiology
R&D Projects	LM2015055 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	MBU-M - RVO:61388971
UT WOS	000410463600004
EID SCOPUS	85026859373
DOI	10.1016/j.jtbi.2017.07.024
Annotation	Critical behaviour pervades scientific disciplines as diverse as geology, economy or sociology. The critical behaviour of cell control systems is an open issue whose role has not yet been fully explored. The control of the expression of lambda phage DNA in the host cell can be classified as a system with critical behaviour. Lambda phage is a virus that infects Escherichia coli. Its core genes maintain one of two states, lysogeny or lysis. Current knowledge of the lambda phage genetic network allows to build a computational model of transcriptional control of the genes involved in the lytic-lysogenic switch and to simulate the temporal changes of their expression. Here, we focused on the computational simulation of these gene expressions to demonstrate critical behaviour of the system.
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2018

Number of the records: 1