Number of the records: 1

The chemical profile and pharmacodynamic properties of extracellular Wollea saccata biopolymer

SYSNO ASEP	0478834
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The chemical profile and pharmacodynamic properties of extracellular Wollea saccata biopolymer
Author(s)	Šutovská, M. (SK) Kočmálová, M. (SK) Pappová, L. (SK) Fraňová, S. (SK) Chyba, A. (SK) Kopecký, Jiří (MBU-M)_ORCID Lukavský, Jaromír (BU-J)_{RID, ORCID} Cepák, Vladislav (BU-J)_RID Capek, P. (SK)
Source Title	International Journal of Biological Macromolecules. - : Elsevier - ISSN 0141-8130 Roč. 103, OCT 2017 (2017), s. 863-869
Number of pages	7 s.
Language	eng - English
Country	NL - Netherlands
Keywords	Wollea saccata ; Extracellular proteoglycan ; Pharmacodynamic properties
Subject RIV	EE - Microbiology, Virology
OECD category	Microbiology
Subject RIV - cooperation	Institute of Botany - Biotechnology ; Bionics
R&D Projects	TE01020080 GA TA ČR - Technology Agency of the Czech Republic (TA ČR)
Institutional support	MBU-M - RVO:61388971 ; BU-J - RVO:67985939
UT WOS	000408286400099
EID SCOPUS	85019673689
DOI	10.1016/j.ijbiomac.2017.05.014
Annotation	Microalgae organisms are of interest for many biotechnology applications due to the production of a wide range of biologically active compounds. Incubation of Wollea saccata in a large scale afforded a mucilaginous, high molecular weight biopolymer composed of carbohydrate, protein and phenolic compounds. Sugar moiety was rich in hexoses (60%) and 6-deoxyhexoses (31%), while only 9% of pentoses was identified. Methylation analysis revealed about 40 types of methylated sugar derivatives, suggesting a very complex structure of Wollea biopolymer. Pharmacological studies revealed new pharmacodynamic properties of cyanobacteria biopolymer, i.e. antitussive and bronchodilatory. Biopolymer was able to suppress the cough reflex induced by chemical tussigen, but its effect was lower than that of codeine, the strongest antitussive agent. The bronchodilatory effect was similar or higher than the effect of salbutamol, a bronchodilatory drug used in a clinical practice. In pharmacological studies, there were no signs of toxicity or side effects in the animals following administration of Wollea biopolymer.
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2018

Number of the records: 1