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Identification of a hybrid myocardial zone in the mammalian heart after birth
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SYSNO ASEP 0477526 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Identification of a hybrid myocardial zone in the mammalian heart after birth Author(s) Tian, X. (CN)
Li, Y. (CN)
He, L. (CN)
Zhang, H. (CN)
Huang, X. (CN)
Liu, Q. (CN)
Pu, W. (CN)
Zhang, LB. (CN)
Li, Yi. (CN)
Zhao, H. (CN)
Wang, Z. (CN)
Zhu, J. (CN)
Nie, Y. (CN)
Hu, S. (CN)
Sedmera, David (FGU-C) RID, ORCID, SAI
Zhong, T. P. (CN)
Yu, Y. (CN)
Zhang, L. (CN)
Yan, Y. (CN)
Qiao, Z. (CN)
Wang, Q-D. (SE)
Wu, S. M. (US)
Pu, W. T. (US)
Anderson, R. H. (GB)
Zhou, B. (CN)Article number 87 Source Title Nature Communications. - : Nature Publishing Group
Roč. 8, Jul 20 (2017)Number of pages 16 s. Language eng - English Country GB - United Kingdom Keywords left-ventricular noncompaction ; lineage tracing ; coronary-arteries ; cardiomyocyte proliferation ; gene-expression Subject RIV EA - Cell Biology OECD category Anatomy and morphology (plant science to be 1.6) R&D Projects GA13-12412S GA ČR - Czech Science Foundation (CSF) GA16-02972S GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 UT WOS 000405900400004 EID SCOPUS 85025436239 DOI 10.1038/s41467-017-00118-1 Annotation Noncompaction cardiomyopathy is characterized by the presence of extensive trabeculations, which could lead to heart failure and malignant arrhythmias. How trabeculations resolve to form compact myocardium is poorly understood. Elucidation of this process is critical to understanding the pathophysiology of noncompaction disease. Here we use genetic lineage tracing to mark the Nppa(+) or Hey(2+) cardiomyocytes as trabecular and compact components of the ventricular wall. We find that Nppa(+) and Hey(2+) cardiomyocytes, respectively, from the endocardial and epicardial zones of the ventricular wall postnatally. Interposed between these two postnatal layers is a hybrid zone, which is composed of cells derived from both the Nppa(+) and Hey(2+) populations. Inhibition of the fetal Hey(2+) cell contribution to the hybrid zone results in persistence of excessive trabeculations in postnatal heart. Our findings indicate that the expansion of Hey(2+) fetal compact component, and its contribution to the hybrid myocardial zone, are essential for normal formation of the ventricular walls. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2018
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