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An integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors

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    SYSNO ASEP0477421
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleAn integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors
    Author(s) Vettorazzi, M. (AR)
    Angelina, E. (AR)
    Lima, S. (US)
    Goněc, T. (CZ)
    Otevřel, J. (CZ)
    Marvanová, P. (CZ)
    Padrtová, T. (CZ)
    Mokrý, P. (CZ)
    Bobáľ, P. (CZ)
    Acosta, L. M. (CO)
    Palma, A. (CO)
    Cobo, J. (ES)
    Bobálová, Janette (UIACH-O) RID, ORCID
    Csollei, J. (CZ)
    Malik, I. (SK)
    Alvarez, S. (AR)
    Spiegel, S. (US)
    Jampílek, J. (SK)
    Enriz, R. D. (AR)
    Number of authors19
    Source TitleEuropean Journal of Medicinal Chemistry. - : Elsevier - ISSN 0223-5234
    Roč. 139, OCT (2017), s. 461-481
    Number of pages21 s.
    Publication formPrint - P
    Languageeng - English
    CountryFR - France
    Keywordssphingosine kinase 1 inhibitors ; bioassays ; molecular modelling ; virtual screening
    Subject RIVCB - Analytical Chemistry, Separation
    OECD categoryAnalytical chemistry
    Institutional supportUIACH-O - RVO:68081715
    UT WOS000412788200037
    EID SCOPUS85027402441
    DOI10.1016/j.ejmech.2017.08.017
    AnnotationSphingosine kinase 1 is a promising new molecular target for therapeutic intervention in cancer and inflammatory diseases. The main objective of this work was to find new and
    more potent inhibitors for this enzyme possessing different structural scaffolds than those of the known inhibitors.
    WorkplaceInstitute of Analytical Chemistry
    ContactIveta Drobníková, drobnikova@iach.cz, Tel.: 532 290 234
    Year of Publishing2018
Number of the records: 1  

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