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The Impact of the Eda Pathway on Tooth Root Development.

SYSNO ASEP	0477375
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The Impact of the Eda Pathway on Tooth Root Development.
Author(s)	Fons Romero, J.M. (GB) Star, H. (GB) Lav, R. (GB) Watkins, S. (GB) Harrison, M. (GB) Hovořáková, Mária (UEM-P)_RID Headon, D. (GB) Tucker, Abigail (UEM-P)
Source Title	Journal of Dental Research. - : Sage - ISSN 0022-0345 Roč. 96, č. 11 (2017), s. 1290-1297
Number of pages	8 s.
Language	eng - English
Country	US - United States
Keywords	tooth ; ectodermal dysplasia ; epithelium
Subject RIV	EA - Cell Biology
OECD category	Developmental biology
R&D Projects	GB14-37368G GA ČR - Czech Science Foundation (CSF)
Institutional support	UEM-P - RVO:68378041
UT WOS	000411431200014
EID SCOPUS	85029827753
DOI	10.1177/0022034517725692
Annotation	The Eda pathway (Eda, Edar, Edaradd) plays an important role in tooth development, determining tooth number, crown shape, and enamel formation. Here we show that the Eda pathway also plays a key role in root development. Edar (the receptor) is expressed in Hertwig's epithelial root sheath (HERS) during root development, with mutant mice showing a high incidence of taurodontism: large pulp chambers lacking or showing delayed bifurcation or trifurcation of the roots. The mouse upper second molars in the Eda pathway mutants show the highest incidence of taurodontism, this enhanced susceptibility being matched in human patients with mutations in EDA-A1. These taurodont teeth form due to defects in the direction of extension of the HERS from the crown, associated with a more extensive area of proliferation of the neighboring root mesenchyme. In those teeth where the angle at which the HERS extends from the crown is very wide and therefore more vertical, the mutant HERSs fail to reach toward the center of the tooth in the normal furcation region, and taurodont teeth are created. The phenotype is variable, however, with milder changes in angle and proliferation leading to normal or delayed furcation. This is the first analysis of the role of Eda in the root, showing a direct role for this pathway during postnatal mouse development, and it suggests that changes in proliferation and angle of HERS may underlie taurodontism in a range of syndromes.
Workplace	Institute of Experimental Medicine
Contact	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Year of Publishing	2018

Number of the records: 1