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Role of Primary Cilia in Odontogenesis

SYSNO ASEP	0477095
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Role of Primary Cilia in Odontogenesis
Author(s)	Hampl, Marek (UZFG-Y)_ORCID Celá, Petra (UZFG-Y)_RID Szabo-Rogers, H. L. (US) Kunová Bosáková, M. (CZ) Dosedělová, Hana (UZFG-Y) Krejčí, P. (CZ) Buchtová, Marcela (UZFG-Y)_{RID, ORCID}
Source Title	Journal of Dental Research. - : Sage - ISSN 0022-0345 Roč. 96, č. 9 (2017), s. 965-974
Number of pages	10 s.
Publication form	Print - P
Language	eng - English
Country	US - United States
Keywords	craniofacial anomalies ; growth/development ; mineralized tissue/development
Subject RIV	FF - HEENT, Dentistry
OECD category	Dentistry, oral surgery and medicine
R&D Projects	EF15_003/0000460 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA17-14886S GA ČR - Czech Science Foundation (CSF)
Institutional support	UZFG-Y - RVO:67985904
UT WOS	000406054800001
EID SCOPUS	85025612713
DOI	10.1177/0022034517713688
Annotation	Primary cilium is a solitary organelle that emanates from the surface of most postmitotic mammalian cells and serves as a sensory organelle, transmitting the mechanical and chemical cues to the cell. Primary cilia are key coordinators of various signaling pathways during development and maintenance of tissue homeostasis. The emerging evidence implicates primary cilia function in tooth development. Primary cilia are located in the dental epithelium and mesenchyme at early stages of tooth development and later during cell differentiation and production of hard tissues. The cilia are present when interactions between both the epithelium and mesenchyme are required for normal morphogenesis. As the primary cilium coordinates several signaling pathways essential for odontogenesis, ciliary defects can interrupt the latter process. Genetic or experimental alterations of cilia function lead to various developmental defects, including supernumerary or missing teeth, enamel and dentin hypoplasia, or teeth crowding. Moreover, dental phenotypes are observed in ciliopathies, including Bardet-Biedl syndrome, Ellis-van Creveld syndrome, Weyers acrofacial dysostosis, cranioectodermal dysplasia, and oral-facial-digital syndrome, altogether demonstrating that primary cilia play a critical role in regulation of both the early odontogenesis and later differentiation of hard tissue-producing cells. Here, we summarize the current evidence for the localization of primary cilia in dental tissues and the impact of disrupted cilia signaling on tooth development in ciliopathies.
Workplace	Institute of Animal Physiology and Genetics
Contact	Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
Year of Publishing	2018

Number of the records: 1