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Cell-based Tolerogenic Therapy, Experience from Animal Models of Multiple Sclerosis, Type 1 Diabetes and Rheumatoid Arthritis
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SYSNO ASEP 0477084 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cell-based Tolerogenic Therapy, Experience from Animal Models of Multiple Sclerosis, Type 1 Diabetes and Rheumatoid Arthritis Author(s) Stojanovic, I. (RS)
Dimitrijevic, M. (RS)
Vives-Pi, M. (ES)
Mansilla, M.J. (ES)
Pujol-Autonell, I. (ES)
Rodriguez-Fernandez, S. (ES)
Pálová-Jelínková, L. (CZ)
Funda, David P. (MBU-M) RID, ORCID
Gruden-Movsesijan, A. (RS)
Sofronic-Milosavljevic, L. (RS)
Hilkens, C.M.U. (RS)
Martínez-Cáceres, E. (ES)
Miljković, D. (RS)Source Title Current Pharmaceutical Design - ISSN 1381-6128
Roč. 23, č. 18 (2017), s. 2623-2643Number of pages 21 s. Language eng - English Country GB - United Kingdom Keywords Cell-based tolerogenic therapy ; regulatory T cells ; tolerogenic dendritic cells Subject RIV EE - Microbiology, Virology OECD category Microbiology R&D Projects GA15-24487S GA ČR - Czech Science Foundation (CSF) Institutional support MBU-M - RVO:61388971 UT WOS 000405678800007 EID SCOPUS 85025164921 DOI 10.2174/1381612823666170214120708 Annotation Cell-based tolerogenic therapy is a promising approach for the treatment of autoimmune diseases and transplant rejection. Regulatory T cells and tolerogenic dendritic cells have been particularly explored in the treatment of various autoimmune disorders in experimental models of disease. Although some of these cells have already been tested in a limited number of clinical trials, there is still a need for preclinical research on tolerogenic cells in animal models of autoimmunity. This review will focus on the relevance of data obtained from studies in experimental animal models for the use of tolerogenic cell-based therapy in humans. Also, perspectives for further improvement of tolerogenic cell preparation towards enhanced suppressive activity and stability of the cells will be discussed. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2018
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