Number of the records: 1
Atherogenic Impact of Lecithin-Cholesterol Acyltransferase and Its Relation to Cholesterol Esterification Rate in HDL (FERHDL) and AIP [log(TG/HDL-C)] Biomarkers: The Butterfly Effect?
- 1.
SYSNO ASEP 0476782 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Atherogenic Impact of Lecithin-Cholesterol Acyltransferase and Its Relation to Cholesterol Esterification Rate in HDL (FERHDL) and AIP [log(TG/HDL-C)] Biomarkers: The Butterfly Effect? Author(s) Dobiášová, Milada (FGU-C) RID Source Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 66, č. 2 (2017), s. 193-203Number of pages 11 s. Language eng - English Country CZ - Czech Republic Keywords lecithin-cholesterol acyltransferase (LCAT) ; atherosclerosis ; FERHDL (fractional esterification rate in HDL) ; AIP (atherogenic index of plasma, log(TG/HDL-C) ; biomarkers of cardiometabolic risk ; lipoprotein particle size Subject RIV FA - Cardiovascular Diseases incl. Cardiotharic Surgery OECD category Endocrinology and metabolism (including diabetes, hormones) Institutional support FGU-C - RVO:67985823 UT WOS 000404258800003 EID SCOPUS 85019173079 DOI 10.33549/physiolres.933621 Annotation The atherogenic impact and functional capacity of LCAT was studied and discussed over a half century. This review aims to clarify the key points that may affect the final decision on whether LCAT is an anti-atherogenic or atherogenic factor. There are three main processes involving the efflux of free cholesterol from peripheral cells, LCAT action in intravascular pool where cholesterol esterification rate is under the control of HDL, LDL and VLDL subpopulations, and finally the destination of newly produced cholesteryl esters either to the catabolism in liver or to a futile cycle with apoB lipoproteins. The functionality of LCAT substantially depends on its mass together with the composition of the phospholipid bilayer as well as the saturation and the length of fatty acyls and other effectors about which we know yet nothing. Over the years, LCAT puzzle has been significantly supplemented but yet not so satisfactory as to enable how to manipulate LCAT in order to prevent cardiometabolic events. It reminds the butterfly effect when only a moderate change in the process of transformation free cholesterol to cholesteryl esters may cause a crucial turn in the intended target. On the other hand, two biomarkers – FERHDL (fractional esterification rate in HDL) and AIP [log(TG/HDL-C)] can offer a benefit to identify the risk of cardiovascular disease (CVD). They both reflect the rate of cholesterol esterification by LCAT and the composition of lipoprotein subpopulations that controls this rate. In clinical practice, AIP can be calculated from the routine lipid profile with help of AIP calculator www.biomed.cas.cz/fgu/aip/calculator.php. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2018
Number of the records: 1