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Self-assembled chitosan-alginate polyplex nanoparticles containing temoporfin

SYSNO ASEP	0476354
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Self-assembled chitosan-alginate polyplex nanoparticles containing temoporfin
Author(s)	Brezaniova, I. (CZ) Trousil, Jiří (UMCH-V)_{RID, ORCID} Černochová, Zulfiya (UMCH-V)_{RID, ORCID} Král, V. (CZ) Hrubý, Martin (UMCH-V)_{RID, ORCID} Štěpánek, Petr (UMCH-V)_{RID, ORCID} Šlouf, Miroslav (UMCH-V)_{RID, ORCID}
Source Title	Colloid and Polymer Science - ISSN 0303-402X Roč. 295, č. 8 (2017), s. 1259-1270
Number of pages	12 s.
Language	eng - English
Country	DE - Germany
Keywords	chitosan ; sodium alginate ; temoporfin
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
R&D Projects	LQ1604 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA16-02870S GA ČR - Czech Science Foundation (CSF)
	NV15-25781A GA MZd - Ministry of Health (MZ)
	LO1507 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	UMCH-V - RVO:61389013
UT WOS	000406174700002
EID SCOPUS	85008514396
DOI	10.1007/s00396-016-3992-6
Annotation	The aim of this study was to develop biocompatible polyplex nanoparticles with physicochemical properties suitable for the delivery of photosensitizer temoporfin. We prepared, characterized, and compared the two types of polyplex nanoformulations consisting of sodium alginate in combination with chitosan polymer or chitosan oligomer lactate. We obtained the polyplex system by multiple electrostatic interactions between cationic chitosan and anionic alginate and identified key process parameters. Particle size distribution, dispersity, and zeta potential were determined by dynamic light scattering (DLS), and the diameter and the morphology of the individual particles were visualized by a transmission electron microscopy (TEM). It was found that size distribution of the polyplex nanoparticles depends on the concentrations of chitosan and alginate stock solutions and the order and ratio of addition of stock solutions as well as on the pH of the resulting mixture. It appears that the nanoparticles are homogeneous, although micrographs indicate some (vague, indistinct) core-shell structure. The nanoparticles are stable at pH 7.4 (pH of blood plasma) and show only very little drug leak in experiment modeling conditions of blood pool transport to target tissues.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2018

Number of the records: 1