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Study of Asymmetric Stereoselective Hydrogenation in Presence of Ionic Liquid in Microfluidic Chip Reactor.

SYSNO ASEP	0475758
Document Type	C - Proceedings Paper (int. conf.)
R&D Document Type	The record was not marked in the RIV
Title	Study of Asymmetric Stereoselective Hydrogenation in Presence of Ionic Liquid in Microfluidic Chip Reactor.
Author(s)	Vychodilová, Hana (UCHP-M)_{RID, SAI} Stavárek, Petr (UCHP-M)_{RID, ORCID, SAI} Hejda, Stanislav (UCHP-M)_{RID, ORCID, SAI} Pěnkavová, Věra (UCHP-M)_{RID, ORCID, SAI} Bendová, Magdalena (UCHP-M)_{RID, ORCID, SAI} Vlček, Dalibor (UCHP-M)_SAI Klusoň, Petr (UCHP-M)_{RID, ORCID, SAI}
Source Title	Proceedings. - Bratislava : Slovak Society of Chemical Engineering, 2017 / Blahušiak M. ; Mihal M. - ISBN 978-80-89597-58-1
Pages	s. 739
Number of pages	1 s.
Publication form	Medium - C
Action	International Conference of SSCHE /44./
Event date	22.05.2017 - 26.05.2017
VEvent location	Demänovská dolina
Country	SK - Slovakia
Event type	EUR
Language	eng - English
Country	SK - Slovakia
Keywords	microfluidic chip reactor ; stereoselective hydrogenation ; ionic liquid
Subject RIV	CI - Industrial Chemistry, Chemical Engineering
OECD category	Chemical process engineering
R&D Projects	GA15-04790S GA ČR - Czech Science Foundation (CSF)
Institutional support	UCHP-M - RVO:67985858
Annotation	In recent years, there have been several successful attempts of microreactor application to production of specialty chemicals [1,2] mainly for pharma and other related industry fields. In this study, we focused on the application of microfluidic chip reactor to the stereoselective hydrogenation of methylacetoacetate (MAA) to isomeric (R)-(+) or (S)-(-)-methyl-3-hydroxybutanoates over a chiral ([RuCl((R)-BINAP)(p-cymene)]Cl) complex [3] immobilized in the mixed [N8222][Tf2N]/methanol/water solvent phase, and performed inside of a microfluidic chip reactor. A presence of ionic liquid (quarternary ammonium salts) allows for an easy separation of this catalyst via its pseudo-immobilization.
Workplace	Institute of Chemical Process Fundamentals
Contact	Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227
Year of Publishing	2018

Number of the records: 1