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100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB

SYSNO ASEP	0475331
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB
Author(s)	Goebel, J. (CH) Promerová, Marta (UBO-W) Bonadonna, F. (FR) McCoy, K. D. (FR) Serbielle, C. (FR) Strandh, M. (FR) Yannic, G. (FR) Burri, R. (DE) Fumagalli, L. (CH)
Number of authors	9
Source Title	BMC Genomics. - : BioMed Central - ISSN 1471-2164 Roč. 18, č. 460 (2017), s. 1-9
Number of pages	9 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	Birds ; Birth-death evolution ; Concerted evolution ; Gene duplication ; Gene conversion ; Major histocompatibility complex ; Recombination
Subject RIV	EG - Zoology
OECD category	Genetics and heredity (medical genetics to be 3)
R&D Projects	GAP505/10/1871 GA ČR - Czech Science Foundation (CSF)
Institutional support	UBO-W - RVO:68081766
UT WOS	000413749900001
EID SCOPUS	85020646288
DOI	10.1186/s12864-017-3839-7
Annotation	Background: Gene duplication has led to a most remarkable adaptation involved in vertebrates’ host-pathogen arms-race, the major histocompatibility complex (MHC). However, MHC duplication history is as yet poorly understood in non-mammalian vertebrates, including birds. Results: Here, we provide evidence for the evolution of two ancient avian MHC class IIB (MHCIIB) lineages by a duplication event prior to the radiation of all extant birds >100 million years ago, and document the role of concerted evolution in eroding the footprints of the avian MHCIIB duplication history. Conclusions: Our results suggest that eroded footprints of gene duplication histories may mimic birth-death evolution and that in the avian MHC the presence of the two lineages may have been masked by elevated rates of concerted evolution in several taxa. Through the presence of a range of intermediate evolutionary stages along the homogenizing process of concerted evolution, the avian MHCIIB provides a remarkable illustration of the erosion of multigene family duplication history.
Workplace	Institute of Vertebrate Biology
Contact	Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524
Year of Publishing	2018

Number of the records: 1