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Glycosylation of voltage-gated calcium channels in health and disease

SYSNO ASEP	0475298
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Glycosylation of voltage-gated calcium channels in health and disease
Author(s)	Lazniewska, Joanna (UOCHB-X)_ORCID Weiss, Norbert (UOCHB-X)_{ORCID, RID}
Source Title	Biochimica Et Biophysica Acta-Biomembranes. - : Elsevier - ISSN 0005-2736 Roč. 1859, č. 5 (2017), s. 662-668
Number of pages	7 s.
Language	eng - English
Country	NL - Netherlands
Keywords	calcium channels ; voltage-gated calcium channels ; N-glycosylation ; ancillary subunit ; trafficking ; stability
Subject RIV	CE - Biochemistry
OECD category	Biochemistry and molecular biology
R&D Projects	GA15-13556S GA ČR - Czech Science Foundation (CSF)
	7AMB15FR015 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	UOCHB-X - RVO:61388963
UT WOS	000398870800002
EID SCOPUS	85012113504
DOI	10.1016/j.bbamem.2017.01.018
Annotation	Voltage-gated calcium channels (VGCCs) are transmembrane proteins that translate electrical activities into intracellular calcium elevations and downstream signaling pathways. They serve essential physiological functions including communication between nerve cells, muscle contraction, cardiac activity, and release of hormones and neurotransmitters. Asparagine-linked glycosylation has emerged as an essential post-translational modification to control the number of channels embedded in the plasma membrane but also their functional gating properties. This review provides a comprehensive overview about the current state of knowledge on the role of glycosylation in the expression and functioning of VGCCs, and discusses how variations in the glycosylation of the channel proteins can contribute to pathological conditions.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2018

Number of the records: 1