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Optical imaging of localized chemical events using programmable diamond quantum nanosensors
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SYSNO ASEP 0475005 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Optical imaging of localized chemical events using programmable diamond quantum nanosensors Author(s) Rendler, T. (DE)
Neburková, Jitka (UOCHB-X) RID, ORCID
Zemek, O. (CZ)
Kotek, J. (CZ)
Zappe, A. (DE)
Chu, Z. (DE)
Cígler, Petr (UOCHB-X) RID, ORCID
Wrachtrup, J. (DE)Article number 14701 Source Title Nature Communications. - : Nature Publishing Group
Roč. 8, Mar 20 (2017)Number of pages 9 s. Language eng - English Country GB - United Kingdom Keywords fluorescent nanodiamonds ; lanthanide(III) complexes ; ambient conditions Subject RIV BO - Biophysics OECD category Biophysics R&D Projects GA16-16336S GA ČR - Czech Science Foundation (CSF) Institutional support UOCHB-X - RVO:61388963 UT WOS 000396666300001 EID SCOPUS 85015807223 DOI 10.1038/ncomms14701 Annotation Development of multifunctional nanoscale sensors working under physiological conditions enables monitoring of intracellular processes that are important for various biological and medical applications. By attaching paramagnetic gadolinium complexes to nanodiamonds (NDs) with nitrogen-vacancy (NV) centres through surface engineering, we developed a hybrid nanoscale sensor that can be adjusted to directly monitor physiological species through a proposed sensing scheme based on NV spin relaxometry. We adopt a single-step method to measure spin relaxation rates enabling time-dependent measurements on changes in pH or redox potential at a submicrometre-length scale in a microfluidic channel that mimics cellular environments. Our experimental data are reproduced by numerical simulations of the NV spin interaction with gadolinium complexes covering the NDs. Considering the versatile engineering options provided by polymer chemistry, the underlying mechanism can be expanded to detect a variety of physiologically relevant species and variables. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2018 Electronic address https://www.nature.com/articles/ncomms14701
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