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Which component of treatment is important for changes of cortical epileptic afterdischarges after status epilepticus in immature rats?

SYSNO ASEP	0475001
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Which component of treatment is important for changes of cortical epileptic afterdischarges after status epilepticus in immature rats?
Author(s)	Tsenov, Grygoriy (FGU-C)_{RID, ORCID} Kubová, Hana (FGU-C)_{RID, ORCID} Mareš, Pavel (FGU-C)_{RID, ORCID}
Source Title	Neuroscience Letters. - : Elsevier - ISSN 0304-3940 Roč. 644, Mar 22 (2017), s. 1-4
Number of pages	4 s.
Language	eng - English
Country	IE - Ireland
Keywords	status epilepticus ; immature rats ; pilocarpine ; lithium chloride ; paraldehyde ; cortical epileptic afterdischarges
Subject RIV	FH - Neurology
OECD category	Neurosciences (including psychophysiology
R&D Projects	GBP304/12/G069 GA ČR - Czech Science Foundation (CSF)
	GAP302/10/0971 GA ČR - Czech Science Foundation (CSF)
	GA15-16605S GA ČR - Czech Science Foundation (CSF)
Institutional support	FGU-C - RVO:67985823
UT WOS	000407529300001
EID SCOPUS	85013790767
DOI	10.1016/j.neulet.2017.02.043
Annotation	Role of lithium chloride and paraldehyde in acute changes after lithium-pilocarpine status epilepticus (SE) induced at postnatal day 12 was studied in 15-day-old rats. In addition to SE group four other groups were formed: naive animals without any injection, lithium chloride group, paraldehyde group and lithium-paraldehyde group. Cortical epileptic afterdischarges (CxADs) induced by increasing intensities of stimulation current were used as a measure of excitability. SE animals did not exhibit any change in duration of CxADs with increasing stimulation intensity in contrast to na ve control with a progressive prolongation of CxAD. LiCI group was similar to SE rats whereas paraldehyde and lithium-paraldehyde groups exhibited some progress in duration of ADs. Lithium chloride participates in short-term changes of CxADs after SE. Paraldehyde and combination of lithium paraldehyde are similar to na ve controls.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2018

Number of the records: 1