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Accuracy of rate coding: When shorter time window and higher spontaneous activity help
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SYSNO ASEP 0474687 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Accuracy of rate coding: When shorter time window and higher spontaneous activity help Author(s) Leváková, Marie (FGU-C) RID, ORCID
Tamborrino, M. (AT)
Košťál, Lubomír (FGU-C) RID, ORCID, SAI
Lánský, Petr (FGU-C) RID, ORCIDArticle number 022310 Source Title Physical Review E. - : American Physical Society - ISSN 2470-0045
Roč. 95, č. 2 (2017)Number of pages 9 s. Language eng - English Country US - United States Keywords rate coding ; observation window ; spontaneous activity ; Fisher information ; perfect integrate-and-fire model ; Wiener process Subject RIV BB - Applied Statistics, Operational Research OECD category Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology R&D Projects GA15-08066S GA ČR - Czech Science Foundation (CSF) 7AMB17AT048 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support FGU-C - RVO:67985823 UT WOS 000394665400006 EID SCOPUS 85014384567 DOI 10.1103/PhysRevE.95.022310 Annotation It is widely accepted that neuronal firing rates contain a significant amount of information about the stimulus intensity. Nevertheless, theoretical studies on the coding accuracy inferred from the exact spike counting distributions are rare. We present an analysis based on the number of observed spikes assuming the stochastic perfect integrate-and-fire model with a change point, representing the stimulus onset, for which we calculate the corresponding Fisher information to investigate the accuracy of rate coding. We analyze the effect of changing the duration of the time window and the influence of several parameters of the model, in particular the level of the presynaptic spontaneous activity and the level of random fluctuation of the membrane potential, which can be interpreted as noise of the system. The results show that the Fisher information is nonmonotonic with respect to the length of the observation period. This counterintuitive result is caused by the discrete nature of the count of spikes. We observe also that the signal can be enhanced by noise, since the Fisher information is nonmonotonic with respect to the level of spontaneous activity and, in some cases, also with respect to the level of fluctuation of the membrane potential. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2018
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