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Hyaluronan polymeric micelles for topical drug delivery
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SYSNO ASEP 0474586 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Hyaluronan polymeric micelles for topical drug delivery Author(s) Šmejkalová, D. (CZ)
Muthný, T. (CZ)
Nešporová, K. (CZ)
Hermannová, M. (CZ)
Achbergerová, E. (CZ)
Huerta-Angelesa, G. (CZ)
Marek Svoboda, M. (CZ)
Čepa, M. (CZ)
Machalová, V. (CZ)
Luptáková, Dominika (MBU-M) ORCID, RID
Velebný, V. (CZ)Source Title Carbohydrate Polymers. - : Elsevier - ISSN 0144-8617
Roč. 156, JAN 20 (2017), s. 86-96Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords Skin penetration ; Polymeric micelle ; Hyaluronan Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology Institutional support MBU-M - RVO:61388971 UT WOS 000388110900011 EID SCOPUS 84986286533 DOI 10.1016/j.carbpol.2016.09.013 Annotation Nanosized materials offer promising strategy for topical drug delivery due to their enhancing effect on drug percutaneous transport across the stratum corneum barrier. In this work, polymeric micelles made from hydrophobized hyaluronic acid (HA) were probed for skin delivery. Compared to non-polymeric micelle solutions containing similar drug amount, in vitro skin penetration analysis indicated 3 times larger deposition of drug in the epidermis and 6 times larger drug deposition in the dermis after 5 h of topical treatment in Franz diffusion cells. The drug deposition was further increased with prolonged time of topical treatment. Laser confocal microscopy revealed the accumulation of both, the HA forming the vehicle and the payload, in the epidermis and dermis. Although fluorescent labeling of the HA would suggest co-transport of the HA and the drug, loading FRET pair dyes in the micellar core clearly demonstrated gradual micelle disruption with increasing skin depth. Transcellular penetration was the predominant pathway for the loaded drug. The HA polymeric micelles also demonstrated increased bioactivity of loaded compound in vitro and in vivo. In addition, the loaded micelles were found to be stable in cream formulations and thus they have great potential for topical applications for cosmetic and pharmaceutical purposes. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2018
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