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The effects of liraglutide in mice with diet-induced obesity studied by metabolomics
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SYSNO ASEP 0474423 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The effects of liraglutide in mice with diet-induced obesity studied by metabolomics Author(s) Bugáňová, M. (CZ)
Pelantová, H. (CZ)
Holubová, M. (CZ)
Šedivá, B. (CZ)
Maletínská, L. (CZ)
Železná, B. (CZ)
Kuneš, Jaroslav (FGU-C) RID, ORCID
Kačer, P. (CZ)
Kuzma, M. (CZ)
Haluzík, M. (CZ)Source Title Journal of Endocrinology. - : BioScientifica - ISSN 0022-0795
Roč. 233, č. 1 (2017), s. 93-104Number of pages 12 s. Language eng - English Country GB - United Kingdom Keywords NMR metabolomics ; obesity type 2 ; diabetes mellitus ; liraglutide ; mouse urine Subject RIV FB - Endocrinology, Diabetology, Metabolism, Nutrition OECD category Endocrinology and metabolism (including diabetes, hormones) Institutional support FGU-C - RVO:67985823 UT WOS 000397242300012 EID SCOPUS 85015671351 DOI 10.1530/JOE-16-0478 Annotation Liraglutide is the glucagon-like peptide-1 receptor agonist widely used for the treatment of type 2 diabetes mellitus. Recently, it has been demonstrated to decrease cardiovascular morbidity and mortality in patients with type 2 diabetes and high cardiovascular risk. Although the major modes of liraglutide action are well-known, its detailed action at the metabolic level has not been studied. To this end, we explored the effect of 2-week liraglutide treatment in C57BL/6 male mice with obesity and diabetes induced by 13 weeks of high-fat diet using NMR spectroscopy to capture the changes in urine metabolic profile induced by the therapy. The liraglutide treatment decreased body and fat pads weight along with blood glucose and triglyceride levels. NMR spectroscopy identified 11 metabolites significantly affected by liraglutide treatment as compared to high-fat diet-fed control group. These metabolites included ones involved in nicotinamide adenine dinucleotide metabolism, beta-oxidation of fatty acids and microbiome changes. Although majority of the metabolites changed after liraglutide treatment were similar as the ones previously identified after vildagliptin administration in a similar mouse model, the changes in creatinine, taurine and trigonelline were specific for liraglutide administration. The significance of these changes and its possible use in the personalization of antidiabetic therapy in humans requires further research. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2018
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