Pharmacological caspase inhibitors: Research towards therapeutic perspectives
1.
SYSNO ASEP
0473501
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Článek ve WOS
Title
Pharmacological caspase inhibitors: Research towards therapeutic perspectives
Author(s)
Kudělová, J. (CZ) Fleischmannová, J. (CZ) Adamová, E. (CZ) Matalová, Eva (UIACH-O)
Source Title
Journal of Physiology and Pharmacology. - : Polskie Towarzystwo Fizjologiczne
- ISSN 0867-5910
Roč. 66, č. 4 (2015), s. 473-482
Number of pages
10 s.
Publication form
Print - P
Language
eng - English
Country
PL - Poland
Keywords
caspase ; caspase inhibitor ; apoptosis
Subject RIV
CB - Analytical Chemistry, Separation
R&D Projects
GA14-28254S GA ČR - Czech Science Foundation (CSF)
Institutional support
UIACH-O - RVO:68081715
UT WOS
000361499800001
EID SCOPUS
84940744287
Annotation
Caspases are key molecules of apoptosis and the inflammatory response. Up-regulation of the caspase cascade contributes to human pathologies such as neurodegenerative and immune disorders. Thus, blocking the excessive apoptosis by pharmacological inhibitors seems promising for therapeutic interventions in such diseases. Caspase inhibitors, both natural and artificial, have been used as research tools and have helped to define the role of the individual caspases in apoptosis and in non-apoptotic processes. Moreover, some caspase inhibitors have demonstrated their therapeutic efficiency in the reduction of cell death and inflammation in animal models of human diseases. However, no drug based on caspase inhibition has been approved on the market until now. Thus, the development of therapeutic approaches that specifically target caspases remains a great challenge and is now the focus of intense biological and clinical interest. Here, we provide a brief review of recent knowledge about pharmacological caspase inhibitors with special focus on their proposed clinical applications.
