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Pharmacological caspase inhibitors: Research towards therapeutic perspectives

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    SYSNO ASEP0473501
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitlePharmacological caspase inhibitors: Research towards therapeutic perspectives
    Author(s) Kudělová, J. (CZ)
    Fleischmannová, J. (CZ)
    Adamová, E. (CZ)
    Matalová, Eva (UIACH-O)
    Source TitleJournal of Physiology and Pharmacology - ISSN 0867-5910
    Roč. 66, č. 4 (2015), s. 473-482
    Number of pages10 s.
    Publication formPrint - P
    Languageeng - English
    CountryPL - Poland
    Keywordscaspase ; caspase inhibitor ; apoptosis
    Subject RIVCB - Analytical Chemistry, Separation
    R&D ProjectsGA14-28254S GA ČR - Czech Science Foundation (CSF)
    Institutional supportUIACH-O - RVO:68081715
    UT WOS000361499800001
    EID SCOPUS84940744287
    AnnotationCaspases are key molecules of apoptosis and the inflammatory response. Up-regulation of the caspase cascade contributes to human pathologies such as neurodegenerative and immune disorders. Thus, blocking the excessive apoptosis by pharmacological inhibitors seems promising for therapeutic interventions in such diseases. Caspase inhibitors, both natural and artificial, have been used as research tools and have helped to define the role of the individual caspases in apoptosis and in non-apoptotic processes. Moreover, some caspase inhibitors have demonstrated their therapeutic efficiency in the reduction of cell death and inflammation in animal models of human diseases. However, no drug based on caspase inhibition has been approved on the market until now. Thus, the development of therapeutic approaches that specifically target caspases remains a great challenge and is now the focus of intense biological and clinical interest. Here, we provide a brief review of recent knowledge about pharmacological caspase inhibitors with special focus on their proposed clinical applications.
    WorkplaceInstitute of Analytical Chemistry
    ContactIveta Drobníková,, Tel.: 532 290 234
    Year of Publishing2017
Number of the records: 1