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Kinetic, thermodynamic and structural analysis of tamiphosphor binding to neuraminidase of H1N1 (2009) pandemic influenza
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SYSNO ASEP 0473216 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Kinetic, thermodynamic and structural analysis of tamiphosphor binding to neuraminidase of H1N1 (2009) pandemic influenza Author(s) Albinana, C. B. (CZ)
Machara, A. (CZ)
Řezáčová, Pavlína (UMG-J) RID
Pachl, P. (CZ)
Konvalinka, J. (CZ)
Kožíšek, M. (CZ)Number of authors 6 Source Title European Journal of Medicinal Chemistry. - : Elsevier - ISSN 0223-5234
Roč. 121, OCT 4 (2016), s. 100-109Number of pages 10 s. Language eng - English Country FR - France Keywords Influenza neuraminidase ; Oseltamivir ; Tamiphosphor ; Isothermal titration calorimetry ; Crystal structure ; Lattice-translocation defect Subject RIV EB - Genetics ; Molecular Biology Institutional support UMG-J - RVO:68378050 UT WOS 000382269700009 DOI 10.1016/j.ejmech.2016.05.016 Annotation Influenza virus causes severe respiratory infections that are responsible for up to half a million deaths worldwide each year. Two inhibitors targeting viral neuraminidase have been approved to date (oseltamivir, zanamivir). However, the rapid development of antiviral drug resistance and the efficient transmission of resistant viruses among humans represent serious threats to public health. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2017
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