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Identification of New World Quails Susceptible to Infection with Avian Leukosis Virus Subgroup J
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SYSNO ASEP 0473165 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Identification of New World Quails Susceptible to Infection with Avian Leukosis Virus Subgroup J Author(s) Plachý, Jiří (UMG-J) RID
Reinišová, Markéta (UMG-J)
Kučerová, Dana (UMG-J)
Šenigl, Filip (UMG-J) RID
Stepanets, Volodymyr (UMG-J) RID
Hron, Tomáš (UMG-J)
Trejbalová, Kateřina (UMG-J) RID
Elleder, Daniel (UMG-J) RID
Hejnar, Jiří (UMG-J) RIDNumber of authors 9 Article number e02002 Source Title Journal of Virology - ISSN 0022-538X
Roč. 91, č. 3 (2017)Number of pages 14 s. Language eng - English Country US - United States Keywords ALV-J ; antiretroviral resistance ; Na+/H+ exchanger ; New World quail ; retroviral receptor Subject RIV EB - Genetics ; Molecular Biology OECD category Virology R&D Projects GA13-30983S GA ČR - Czech Science Foundation (CSF) LO1419 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UMG-J - RVO:68378050 UT WOS 000393194600025 DOI 10.1128/JVI.02002-16 Annotation The J subgroup of avian leukosis virus (ALV-J) infects domestic chickens, jungle fowl, and turkeys. This virus enters the host cell through a receptor encoded by the tvj locus and identified as Na+/H+ exchanger 1. The resistance to avian leukosis virus subgroup J in a great majority of galliform species has been explained by deletions or substitutions of the critical tryptophan 38 in the first extracellular loop of Na+/H+ exchanger 1. Because there are concerns of transspecies virus transmission, we studied natural polymorphisms and susceptibility/resistance in wild galliforms and found the presence of tryptophan 38 in four species of New World quails. The embryo fibroblasts of New World quails are susceptible to infection with avian leukosis virus subgroup J, and the cloned Na+/H+ exchanger 1 confers susceptibility on the otherwise resistant host. New World quails are also susceptible to new avian leukosis virus subgroup J variants but resistant to subgroups A and B and weakly susceptible to subgroups C and D of avian sarcoma/leukosis virus due to obvious defects of the respective receptors. Our results suggest that the avian leukosis virus subgroup J could be transmitted to New World quails and establish a natural reservoir of circulating virus with a potential for further evolution. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2017
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