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RADIOMETRIC DETERMINATION OF THYROTOXIC EFFECTS OF SOME XENOBIOTICS
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SYSNO ASEP 0472832 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title RADIOMETRIC DETERMINATION OF THYROTOXIC EFFECTS OF SOME XENOBIOTICS Author(s) Pavelka, Stanislav (FGU-C) RID Source Title RAD 2015: THE THIRD INTERNATIONAL CONFERENCE ON RADIATION AND APPLICATIONS IN VARIOUS FIELDS OF RESEARCH. - Niš : RAD ASSOC, 2015 / Ristić Goran - ISBN 978-86-80300-01-6 Pages s. 463-466 Number of pages 4 s. Publication form Online - E Action International Conference on Radiation and Applications in Various Fields of Research (RAD) /3./ Event date 08.06.2015 - 12.06.2015 VEvent location Budva Country ME - Montenegro Event type WRD Language eng - English Country ME - Montenegro Keywords bromide ; perchlorate ; thyroid hormones ; radiometric determination ; xenobiotics Subject RIV FB - Endocrinology, Diabetology, Metabolism, Nutrition Institutional support FGU-C - RVO:67985823 UT WOS 000387979700096 Annotation Recently, we have shown in the isolated rat thyroid glands marked effects of excessive exogenous bromide and perchlorate ions on the activity of thyroid peroxidase (TPO), the key enzyme in thyroid hormones (TH) metabolism. Here, we studied in more details effects of an enhanced bromide and/or perchlorate intake on various aspects of iodine metabolism and, consequently, on TH metabolism in the rat. With the use of several radioanalytical methods, including adapted radiometric determination of TPO enzyme activity, we confirmed and quantified the presumed thyrotoxic effects of xenobiotics bromide and perchlorate ions. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2017
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