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Cholesterol oxidation products and their biological importance
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SYSNO ASEP 0472250 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cholesterol oxidation products and their biological importance Author(s) Kulig, W. (FI)
Cwiklik, Lukasz (UOCHB-X) RID, ORCID
Jurkiewicz, P. (CZ)
Rog, T. (FI)
Vattulainen, I. (FI)Source Title Chemistry and Physics of Lipids. - : Elsevier - ISSN 0009-3084
Roč. 199, Sep (2016), s. 144-160Number of pages 17 s. Language eng - English Country IE - Ireland Keywords cholesterol ; oxidation ; oxysterols ; biological membranes ; biophysical properties Subject RIV CF - Physical ; Theoretical Chemistry R&D Projects GBP208/12/G016 GA ČR - Czech Science Foundation (CSF) Institutional support UOCHB-X - RVO:61388963 UT WOS 000381833800014 EID SCOPUS 84959894259 DOI 10.1016/j.chemphyslip.2016.03.001 Annotation The main biological cause of oxysterols is the oxidation of cholesterol. They differ from cholesterol by the presence of additional polar groups that are typically hydroxyl, keto, hydroperoxy, epoxy, or carboxyl moieties. Under typical conditions, oxysterol concentration is maintained at a very low and precisely regulated level, with an excess of cholesterol. Like cholesterol, many oxysterols are hydrophobic and hence confined to cell membranes. However, small chemical differences between the sterols can significantly affect how they interact with other membrane components, and this in turn can have a substantial effect on membrane properties. In this spirit, this review describes the biological importance and the roles of oxysterols in the human body. We focus primarily on the effect of oxysterols on lipid membranes, but we also consider other issues such as enzymatic and nonenzymatic synthesis processes of oxysterols as well as pathological conditions induced by oxysterols. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2017
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