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Nitro-Oleic Acid Prevents Hypoxia- and Asymmetric Dimethylarginine-Induced Pulmonary Endothelial Dysfunction
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SYSNO ASEP 0471939 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Nitro-Oleic Acid Prevents Hypoxia- and Asymmetric Dimethylarginine-Induced Pulmonary Endothelial Dysfunction Author(s) Koudelka, Adolf (BFU-R) ORCID
Ambrožová, Gabriela (BFU-R) RID
Klinke, A. (DE)
Fidlerová, Táňa (BFU-R)
Martíšková, Hana (BFU-R) ORCID
Kuchta, R. (CZ)
Rudolph, T.K. (US)
Kadlec, J. (CZ)
Kuchtová, Z. (CZ)
Woodcock, S.R. (US)
Freeman, B.A. (US)
Kubala, Lukáš (BFU-R) RID, ORCID
Pekarová, Michaela (BFU-R) RIDNumber of authors 13 Source Title Cardiovascular Drugs and Therapy - ISSN 0920-3206
Roč. 30, č. 6 (2016), s. 579-586Number of pages 8 s. Publication form Print - P Language eng - English Country NL - Netherlands Keywords fatty acids ; arterial-hypertension ; oxide synthase ; murine model Subject RIV BO - Biophysics R&D Projects GP13-40824P GA ČR - Czech Science Foundation (CSF) LD15069 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support BFU-R - RVO:68081707 UT WOS 000390066300005 DOI 10.1007/s10557-016-6700-3 Annotation Pulmonary hypertension (PH) represents a serious health complication accompanied with hypoxic conditions, elevated levels of asymmetric dimethylarginine (ADMA), and overall dysfunction of pulmonary vascular endothelium. Since the prevention strategies for treatment of PH remain largely unknown, our study aimed to explore the effect of nitro-oleic acid (OA-NO2), an exemplary nitro-fatty acid (NO2-FA), in human pulmonary artery endothelial cells (HPAEC) under the influence of hypoxia or ADMA. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2017
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