Number of the records: 1  

Decellularized Porcine Pericardium for Cardiovascular Tissue Engineering

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    SYSNO ASEP0471889
    Document TypeC - Proceedings Paper (int. conf.)
    R&D Document TypeConference Paper
    TitleDecellularized Porcine Pericardium for Cardiovascular Tissue Engineering
    Author(s) Marková, Marie (FGU-C)
    Filová, Elena (FGU-C) RID, ORCID
    Matějka, Roman (FGU-C) RID, ORCID, SAI
    Trávníčková, Martina (FGU-C) RID, ORCID, SAI
    Koňařík, M. (CZ)
    Pirk, J. (CZ)
    Bačáková, Lucie (FGU-C) RID, ORCID
    Source TitleCORONARY ARTERY DISEASE 2015. - Bologna : Medimond, 2016 - ISBN 978-88-7587-729-3
    Pagess. 13-16
    Number of pages4 s.
    Publication formPrint - P
    ActionInternational Congress on Coronary Artery Disease /11./
    Event date29.11.2015 - 02.12.2015
    VEvent locationFlorence
    CountryIT - Italy
    Event typeWRD
    Languageeng - English
    CountryIT - Italy
    Keywordsdecellularization ; stem cells ; pericardium
    Subject RIVFA - Cardiovascular Diseases incl. Cardiotharic Surgery
    R&D ProjectsGAP108/12/1168 GA ČR - Czech Science Foundation (CSF)
    TA04011345 GA TA ČR - Technology Agency of the Czech Republic (TA ČR)
    ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    NV15-29153A GA MZd - Ministry of Health (MZ)
    Institutional supportFGU-C - RVO:67985823
    UT WOS000391237200003
    AnnotationBiological prostheses made of decellularized cross-linked bovine pericardium and porcine aortic heart valves or mechanical prostheses are used for transplantation of aortic heart valves. None of these prostheses contain autologous cells. The purpose of our study is to prepare decellularized porcine pericardium, which would be suitable for colonizing with both autologous stem cells and endothelial cells, and subsequently transplanted into a patient. For decellularization, we tested different solutions and time of exposure. Effectiveness of decellularization process was assessed by hematoxylin-eosin staining and Hoechst staining. Extracts of the decellularized pericardium were evaluated for biocompatibility using xCelligence method. Decellularized porcine pericardium seems to be a suitable scaffold for preparing bioartificial heart valves.
    WorkplaceInstitute of Physiology
    ContactLucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
    Year of Publishing2017
Number of the records: 1  

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