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Nanofiber Research - Reaching New Heights

SYSNO ASEP	0467210
Document Type	M - Monograph Chapter
R&D Document Type	Monograph Chapter
Title	Nanofibrous Scaffolds as Promising Cell Carriers for Tissue Engineering
Author(s)	Bačáková, Lucie (FGU-C)_{RID, ORCID} Bačáková, Markéta (FGU-C) Pajorová, Julia (FGU-C) Kudláčková, Radmila (FGU-C) Staňková, Ľubica (FGU-C)_{RID, ORCID} Filová, Elena (FGU-C)_{RID, ORCID} Musílková, Jana (FGU-C)_{RID, ORCID} Potocký, Štěpán (FZU-D)_{RID, ORCID} Kromka, Alexander (FZU-D)_{RID, ORCID, SAI}
Source Title	Nanofiber Research - Reaching New Heights. - InTech : Rijeka, 2016 / Rahman Mohammed Muzibur ; Asiri Abdullah M. - ISBN 978-953-51-2528-0
Pages	s. 29-54
Number of pages	26 s.
Number of pages	252
Publication form	Print - P
Language	eng - English
Country	HR - Croatia
Keywords	nanofibers ; nanoparticles ; natural polymers ; synthetic polymers ; ceramics ; carbon ; diamond ; biomaterial ; biocompatibility ; tissue engineering
Subject RIV	EI - Biotechnology ; Bionics
OECD category	Biomaterials (as related to medical implants, devices, sensors)
Subject RIV - cooperation	Institute of Physics - Physiology
R&D Projects	NV15-33018A GA MZd - Ministry of Health (MZ)
	GA14-04790S GA ČR - Czech Science Foundation (CSF)
	TA04010065 GA TA ČR - Technology Agency of the Czech Republic (TA ČR)
	NV15-32497A GA MZd - Ministry of Health (MZ)
Institutional support	FGU-C - RVO:67985823 ; FZU-D - RVO:68378271
UT WOS	000399645700004
DOI	10.5772/63707
Annotation	Nanofibers are promising cell carriers for tissue engineering of a variety of tissues and organs in the human organism. They have been experimentally used for reconstruction of tissues of cardiovascular, respiratory, digestive, urinary, nervous and musculoskeletal systems. Nanofibers are also promising for drug and gene delivery, construction of biosensors and biostimulators, and wound dressings. Nanofibers can be created from a wide range of natural polymers or synthetic biostable and biodegradable polymers. For hard tissue engineering, polymeric nanofibers can be reinforced with various ceramic, metal-based or carbon-based nanoparticles, or created directly from hard materials. The nanofibrous scaffolds can be loaded with various bioactive molecules, such as growth, differentiation and angiogenic factors, or funcionalized with ligands for the cell adhesion receptors. This review also includes our experience in skin tissue engineering using nanofibers fabricated from polycaprolactone and its copolymer with polylactide, cellulose acetate, and particularly from polylactide nanofibers modified by plasma activation and fibrin coating. In addition, we studied the interaction of human bone-derived cells with nanofibrous scaffolds loaded with hydroxyapatite or diamond nanoparticles. We also created novel nanofibers based on diamond deposition on a SiO2 template, and tested their effects on the adhesion, viability and growth of human vascular endothelial cells.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2017

Number of the records: 1