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Newly developed Ti-Nb-Zr-Ta-Si-Fe biomedical beta titanium alloys with increased strength and enhanced biocompatibility\n

SYSNO ASEP	0466487
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Newly developed Ti-Nb-Zr-Ta-Si-Fe biomedical beta titanium alloys with increased strength and enhanced biocompatibility
Author(s)	Kopová, Ivana (FGU-C)_RID Stráský, J. (CZ) Harcuba, P. (CZ) Landa, Michal (UT-L)_RID Janeček, M. (CZ) Bačáková, Lucie (FGU-C)_{RID, ORCID}
Source Title	Materials Science & Engineering C-Materials for Biological Applications. - : Elsevier - ISSN 0928-4931 Roč. 60, Mar 1 (2016), s. 230-238
Number of pages	9 s.
Language	eng - English
Country	NL - Netherlands
Keywords	elastic modulus ; alloy hardening ; cell growth ; osteogenic cell differentiation ; bone implants
Subject RIV	EI - Biotechnology ; Bionics
Subject RIV - cooperation	Institute of Thermomechanics - Acoustics
R&D Projects	GAP107/12/1025 GA ČR - Czech Science Foundation (CSF)
Institutional support	FGU-C - RVO:67985823 ; UT-L - RVO:61388998
UT WOS	000369204700027
EID SCOPUS	84947944030
DOI	10.1016/j.msec.2015.11.043
Annotation	Beta titanium alloys are promising materials for load-bearing orthopaedic implants due to their excellent corrosion resistance and biocompatibility, low elastic modulus and moderate strength. Metastable beta-Ti alloys can be hardened via precipitation of the alpha phase; however, this has an adverse effect on the elastic modulus. Small amounts of Fe (0-2 wt.%) and Si (0-1 wt.%) were added to Ti-35Nb-7Zr-6Ta (TNZT) biocompatible alloy to increase its strength in beta solution treated condition. Fe and Si additions were shown to cause a significant increase in tensile strength and also in the elastic modulus (from 65 GPa to 85 GPa). However, the elastic modulus of TNZT alloy with Fe and Si additions is still much lower than that of widely used Ti-6A1-4V alloy (115 GPa), and thus closer to that of the bone (10-30 GPa). Si decreases the elongation to failure, whereas Fe increases the uniform elongation thanks to increased work hardening. Primary human osteoblasts cultivated for 21 days on TNZT with 0.5Si + 2Fe (wt.%) reached a significantly higher cell population density and significantly higher collagen I production than cells cultured on the standard Ti-6A1-4V alloy. In conclusion, the Ti-35Nb-7Zr-6Ta-2Fe-0.5Si alloy proves to be the best combination of elastic modulus, strength and also biological properties, which makes it a viable candidate for use in load-bearing implants.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2017

Number of the records: 1