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Optimizing cyanobacterial product synthesis: Meeting the challenges
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SYSNO ASEP 0464727 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Optimizing cyanobacterial product synthesis: Meeting the challenges Author(s) Zavřel, Tomáš (UEK-B) RID, SAI, ORCID
Červený, Jan (UEK-B) RID, ORCID, SAI
Knoop, H. (DE)
Steuer, R. (DE)Source Title Bioengineered - ISSN 2165-5979
Roč. 7, č. 6 (2016), s. 490-496Number of pages 7 s. Language eng - English Country US - United States Keywords MIMS ; biotechnology ; biofuels ; biotechnology ; cyanobacteria ; ethylene ; genome-scale models (GSM) ; photobioreactors ; systems biology Subject RIV EB - Genetics ; Molecular Biology R&D Projects LO1415 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LM2015055 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA15-17367S GA ČR - Czech Science Foundation (CSF) Research Infrastructure CzeCOS II - 90061 - Ústav výzkumu globální změny AV ČR, v. v. i. Institutional support RVO:67179843 - RVO:67179843 UT WOS 000387292200016 EID SCOPUS 84982262073 DOI 10.1080/21655979.2016.1207017 Annotation The synthesis of renewable bioproducts using photosynthetic microorganisms holds great promise. Sustainable industrial applications, however, are still scarce and the true limits of phototrophic production remain unknown. One of the limitations of further progress is our insufficient understanding of the quantitative changes in photoautotrophic metabolism that occur during growth in dynamic environments. We argue that a proper evaluation of the intra- and extracellular factors that limit phototrophic production requires the use of highly-controlled cultivation in photobioreactors, coupled to real-time analysis of production parameters and their evaluation by predictive computational models. In this addendum, we discuss the importance and challenges of systems biology approaches for the optimization of renewable biofuels production. As a case study, we present the utilization of a state-of-the-art experimental setup together with a stoichiometric computational model of cyanobacterial metabolism for quantitative evaluation of ethylene production by a recombinant cyanobacterium Synechocystis sp. PCC 6803. Workplace Global Change Research Institute Contact Nikola Šviková, svikova.n@czechglobe.cz, Tel.: 511 192 268 Year of Publishing 2017
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