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Host-pathogen evolutionary signatures reveal dynamics and future invasions of vampire bat rabies
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SYSNO ASEP 0464042 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Host-pathogen evolutionary signatures reveal dynamics and future invasions of vampire bat rabies Author(s) Streicker, D. G. (GB)
Winternitz, Jamie Caroline (UBO-W) RID, ORCID, SAI
Satterfield, D. A. (US)
Condori-Condori, R. E. (US)
Broos, A. (GB)
Tello, C. (PE)
Recuenco, S. (PE)
Velasco-Villa, A. (US)
Altizer, S. (US)
Valderrama, W. (PE)Number of authors 10 Source Title Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences - ISSN 0027-8424
Roč. 113, č. 39 (2016), s. 10926-10931Number of pages 6 s. Language eng - English Country US - United States Keywords Desmodus ; zoonotic disease ; forecasting ; sex bias ; spatial dynamics Subject RIV GJ - Animal Vermins ; Diseases, Veterinary Medicine Institutional support UBO-W - RVO:68081766 UT WOS 000383954700049 EID SCOPUS 84989939834 DOI 10.1073/pnas.1606587113 Annotation Anticipating how epidemics will spread across landscapes requires understanding host dispersal events that are notoriously difficult to measure. Here, we contrast host and virus genetic signatures to resolve the spatiotemporal dynamics underlying geographic expansions of vampire bat rabies virus (VBRV) in Peru. Phylogenetic analysis revealed recent viral spread between populations that, according to extreme geographic structure in maternally inherited host mitochondrial DNA, appeared completely isolated. In contrast, greater population connectivity in biparentally inherited nuclear microsatellites explained the historical limits of invasions, suggesting that dispersing male bats spread VBRV between genetically isolated female populations. Host nuclear DNA further indicated unanticipated gene flow through the Andes mountains connecting the VBRV-free Pacific coast to the VBRV-endemic Amazon rainforest. By combining Bayesian phylogeography with landscape resistance models, we projected invasion routes through northern Peru that were validated by real-time livestock rabies mortality data. The first outbreaks of VBRV on the Pacific coast of South America could occur by June 2020, which would have serious implications for agriculture, wildlife conservation, and human health. Our results show that combining host and pathogen genetic data can identify sex biases in pathogen spatial spread, which may be a widespread but under-appreciated phenomenon, and demonstrate that genetic forecasting can aid preparedness for impending viral invasions. Workplace Institute of Vertebrate Biology Contact Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Year of Publishing 2017
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