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Peptide-targeted polymer cancerostatics
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SYSNO ASEP 0463656 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Peptide-targeted polymer cancerostatics Author(s) Böhmová, Eliška (UMCH-V) RID
Pola, Robert (UMCH-V) RID, ORCIDSource Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 65, Suppl. 2 (2016), S153-S164Number of pages 12 s. Language eng - English Country CZ - Czech Republic Keywords HPMA copolymers ; tumor targeting ; peptides Subject RIV CD - Macromolecular Chemistry R&D Projects LO1507 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UMCH-V - RVO:61389013 UT WOS 000386686800002 EID SCOPUS 84997522637 Annotation A tumor-targeting drug delivery system consists of a tumor recognition moiety and a directly linked cytotoxic agent or an agent attached to a water-soluble synthetic polymer carrier through a suitable linker. Conjugation of a drug with a polymer carrier can change its solubility, toxicity, biodistribution, blood clearance and therapeutic specificity. Increased therapeutic specificity of a polymer drug can be achieved by the attachment of a targeting moiety (e.g. a lectin, protein, antibody, or peptide) that specifically interacts with receptors on the target cells. A large number of tumor-specific peptides were described in recent years. After a short introduction, some important examples of peptide-targeted conjugates will be described and discussed. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2017 Electronic address http://www.biomed.cas.cz/physiolres/pdf/65%20Suppl%202/65_S153.pdf
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