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Prolactin-releasing peptide: a new tool for obesity treatment

SYSNO ASEP	0463385
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Prolactin-releasing peptide: a new tool for obesity treatment
Author(s)	Kuneš, Jaroslav (UOCHB-X)_{ORCID, RID} Pražienková, Veronika (UOCHB-X)_{RID, ORCID} Popelová, Andrea (UOCHB-X)_{RID, ORCID} Mikulášková, Barbora (UOCHB-X) Zemenová, Jana (UOCHB-X) Maletínská, Lenka (UOCHB-X)_{RID, ORCID}
Source Title	Journal of Endocrinology. - : BioScientifica - ISSN 0022-0795 Roč. 230, č. 2 (2016), R51-R58
Number of pages	8 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	prolactin-releasing peptide ; lipidization ; obesity ; GPR10 ; anorexigenic ; mice
Subject RIV	FB - Endocrinology, Diabetology, Metabolism, Nutrition
R&D Projects	GA15-08679S GA ČR - Czech Science Foundation (CSF)
Institutional support	UOCHB-X - RVO:61388963
UT WOS	000380494400001
EID SCOPUS	84983591558
DOI	10.1530/JOE-16-0046
Annotation	Obesity is an escalating epidemic, but an effective noninvasive therapy is still scarce. For obesity treatment, anorexigenic neuropeptides are promising tools, but their delivery from the periphery to the brain is complicated because peptides have a low stability and limited ability to cross the blood-brain barrier. In this review, we summarize results of several studies with our newly designed lipidized analogs of prolactin-releasing peptide (PrRP). PrRP is involved in feeding and energy balance regulation as demonstrated by obesity phenotypes of both PrRP-and PrRP-receptor-knockout mice. Lipidized PrRP analogs showed binding affinity and signaling in PrRP receptor-expressing cells similar to natural PrRP. Moreover, these analogs showed high binding affinity also to anorexigenic neuropeptide FF (NPFF)-2 receptor. Acute peripheral administration of myristoylated and palmitoylated PrRP analogs to mice and rats induced strong and long-lasting anorexigenic effects and neuronal activation in the brain areas involved in food intake regulation. Two-week-long subcutaneous administration of palmitoylated PrRP31 and myristoylated PrRP20 lowered food intake, body weight, improved metabolic parameters and attenuated lipogenesis in mice with diet-induced obesity. A strong anorexigenic, body weight-reducing and glucose tolerance-improving effect of palmitoylated-PrRP31 was shown also in diet-induced obese rats after its repeated 2-week-long peripheral administration. Thus, the strong anorexigenic and body weight-reducing effects of palmitoylated PrRP31 and myristoylated PrRP20 make these analogs attractive candidates for antiobesity treatment. Moreover, PrRP receptor might be a new target for obesity therapy.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2017

Number of the records: 1