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Sugared biomaterial binding lectins: achievements and perspectives

SYSNO ASEP	0462996
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Sugared biomaterial binding lectins: achievements and perspectives
Author(s)	Bojarová, Pavla (MBU-M)_ORCID Křen, Vladimír (MBU-M)_{RID, ORCID}
Source Title	Biomaterials Science . - : Royal Society of Chemistry - ISSN 2047-4830 Roč. 4, č. 8 (2016), s. 1142-1160
Number of pages	19 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	C-TYPE LECTINS ; AMPHIPHILIC JANUS GLYCODENDRIMERS ; BIOMEDICALLY RELEVANT LECTINS
Subject RIV	CE - Biochemistry
R&D Projects	GC15-02578J GA ČR - Czech Science Foundation (CSF)
Institutional support	MBU-M - RVO:61388971
UT WOS	000380895500001
EID SCOPUS	84979265950
DOI	10.1039/c6bm00088f
Annotation	Lectins, a distinct group of glycan-binding proteins, play a prominent role in the immune system ranging from pathogen recognition and tuning of inflammation to cell adhesion or cellular signalling. The possibilities of their detailed study expanded along with the rapid development of biomaterials in the last decade. The immense knowledge of all aspects of glycan-lectin interactions both in vitro and in vivo may be efficiently used in bioimaging, targeted drug delivery, diagnostic and analytic biological methods. Practically applicable examples comprise photoluminescence and optical biosensors, ingenious three-dimensional carbohydrate microarrays for high-throughput screening, matrices for magnetic resonance imaging, targeted hyperthermal treatment of cancer tissues, selective inhibitors of bacterial toxins and pathogen-recognising lectin receptors, and many others.
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2017

Number of the records: 1