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The role of protease-activated receptor type 2 in nociceptive signaling and pain

SYSNO ASEP	0462321
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The role of protease-activated receptor type 2 in nociceptive signaling and pain
Author(s)	Mrózková, Petra (FGU-C)_{RID, ORCID} Paleček, Jiří (FGU-C)_{RID, ORCID} Špicarová, Diana (FGU-C)_{RID, ORCID}
Source Title	Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408 Roč. 65, č. 3 (2016), s. 357-367
Number of pages	11 s.
Language	eng - English
Country	CZ - Czech Republic
Keywords	protease-activated receptor (PAR2) ; signaling pathways ; nociception ; pain ; spinal cord
Subject RIV	FH - Neurology
R&D Projects	LH12058 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GBP304/12/G069 GA ČR - Czech Science Foundation (CSF)
	GA15-11138S GA ČR - Czech Science Foundation (CSF)
	LH15279 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	FGU-C - RVO:67985823
UT WOS	000382115700001
EID SCOPUS	84979742838
Annotation	Protease-activated receptors (PARs) belong to the G-protein-coupled receptor family, that are expressed in many body tissues especially in different epithelial cells, mast cells and also in neurons and astrocytes. PARs play different physiological roles according to the location of their expression. Increased evidence supports the importance of PARs activation during nociceptive signaling and in the development of chronic pain states. This short review focuses on the role of PAR2 receptors in nociceptive transmission with the emphasis on the modulation at the spinal cord level. PAR2 are cleaved and subsequently activated by endogenous proteases such as tryptase and trypsin. In vivo, peripheral and intrathecal administration of PAR2 agonists induces thermal and mechanical hypersensitivity that is thought to be mediated by PAR2-induced release of pronociceptive neuropeptides and modulation of different receptors. PAR2 activation leads also to sensitization of transient receptor potential channels (TRP) that are crucial for nociceptive signaling and modulation. PAR2 receptors may play an important modulatory role in the development and maintenance of different pathological pain states and could represent a potential target for new analgesic treatments.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2017

Number of the records: 1