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Synthesis, characterization, crystal structures, QSAR study and antibacterial activities of organotin bisphosphoramidates

SYSNO ASEP	0462124
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Synthesis, characterization, crystal structures, QSAR study and antibacterial activities of organotin bisphosphoramidates
Author(s)	Gholivand, K. (IR) Valmoozi, A.A.E. (IR) Gholami, A. (IR) Dušek, Michal (FZU-D)_{RID, ORCID, SAI} Eigner, Václav (FZU-D)_{RID, ORCID} Abolghasemi, S. (IR)
Source Title	Journal of Organometallic Chemistry. - : Elsevier - ISSN 0022-328X Roč. 806, Mar (2016), s. 33-44
Number of pages	12 s.
Language	eng - English
Country	CH - Switzerland
Keywords	bisphosphoramidate ; organotin compounds ; crystal structure ; antibacterial activity ; QSAR
Subject RIV	BM - Solid Matter Physics ; Magnetism
R&D Projects	GA15-12653S GA ČR - Czech Science Foundation (CSF)
Institutional support	FZU-D - RVO:68378271
UT WOS	000370445100005
EID SCOPUS	84976332580
DOI	10.1016/j.jorganchem.2015.09.030
Annotation	Organotin complexes of bisphosphoramidates were prepared by the reaction of SnR1R2R3Cl (where R = alkyl/aryl/Cl) and Ph2P(O)XP(O)Ph2 ligands (where X = diamine). All the compounds were characterized by NMR and IR spectroscopy and X-Ray crystallography. The synthesized compounds were screened for the antibacterial activity against B. cereus and E. coli. Triphenyltin adducts exhibited a marked activity only against Gram-positive bacterium B. Cereus. The correlation matrix of QSAR models and docking analysis confirmed the influence of the net charge (QSn) and polarizability of Sn atom of complexes o n the inhibition of B. cereus.
Workplace	Institute of Physics
Contact	Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579
Year of Publishing	2017

Number of the records: 1