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Real-space path integration is impaired in Alzheimer’s disease and mild cognitive impairment
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SYSNO ASEP 0461568 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Real-space path integration is impaired in Alzheimer’s disease and mild cognitive impairment Author(s) Mokrišová, I. (CZ)
Laczó, J. (CZ)
Andel, R. (CZ)
Gažová, I. (CZ)
Vyhnálek, M. (CZ)
Nedělská, Z. (CZ)
Levčík, David (FGU-C) RID, ORCID
Cerman, J. (CZ)
Vlček, Kamil (FGU-C) RID, ORCID
Hort, J. (CZ)Source Title Behavioural Brain Research. - : Elsevier - ISSN 0166-4328
Roč. 307, Jul 1 (2016), s. 150-158Number of pages 9 s. Language eng - English Country NL - Netherlands Keywords Alzheimer disease ; mild cognitive impairment ; spatial navigation ; hippocampus ; path integration Subject RIV FH - Neurology Institutional support FGU-C - RVO:67985823 UT WOS 000376549000018 EID SCOPUS 84962670696 DOI 10.1016/j.bbr.2016.03.052 Annotation In a newly developed Arena Path Integration Task, we testes subjects suffering Alzheimer’s Disease and amnestic mild cognitive impairment in a navigation without vision to a previously seen goals and back to the start. Both groups of patients were impaired relative to healthy controls in returning back to the start position and their impairment was related to the medial temporal and parietal cortex volumes. Our results suggest that even navigation without vision is impaired in these patients, possibly as a function of medial temporal and parietal cortex neurodegeneration. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2017
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