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Inhaled Cadmium Oxide Nanoparticles: Their in Vivo Fate and Effect on Target Organs

SYSNO ASEP	0460675
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Inhaled Cadmium Oxide Nanoparticles: Their in Vivo Fate and Effect on Target Organs
Author(s)	Dumková, J. (CZ) Vrlíková, Lucie (UZFG-Y)_ORCID Večeřa, Zbyněk (UIACH-O)_RID Putnová, Barbora (UZFG-Y) Dočekal, Bohumil (UIACH-O)_{RID, ORCID} Mikuška, Pavel (UIACH-O)_{RID, ORCID} Fictum, P. (CZ) Hampl, A. (CZ) Buchtová, Marcela (UZFG-Y)_{RID, ORCID}
Source Title	International Journal of Molecular Sciences. - : MDPI Roč. 17, č. 6 (2016), s. 874-893
Number of pages	20 s.
Publication form	Online - E
Language	eng - English
Country	CH - Switzerland
Keywords	nanoparticles ; cadmium oxide ; electron microscopy
Subject RIV	EB - Genetics ; Molecular Biology
Subject RIV - cooperation	Institute of Analytical Chemistry - Analytical Chemistry, Separation
R&D Projects	GAP503/11/2315 GA ČR - Czech Science Foundation (CSF)
	GBP503/12/G147 GA ČR - Czech Science Foundation (CSF)
Institutional support	UZFG-Y - RVO:67985904 ; UIACH-O - RVO:68081715
UT WOS	000378799300088
EID SCOPUS	84971668007
DOI	10.3390/ijms17060874
Annotation	The increasing amount of heavy metals used in manufacturing equivalently increases hazards of environmental pollution by industrial products such as cadmium oxide (CdO) nanoparticles. Here, we aimed to unravel the CdO nanoparticle destiny upon their entry into lungs by inhalations, with the main focus on the ultrastructural changes that the nanoparticles may cause to tissues of the primary and secondary target organs. We indeed found the CdO nanoparticles to be transported from the lungs into secondary target organs by blood. In lungs, inhaled CdO nanoparticles caused significant alterations in parenchyma tissue including hyperemia, enlarged pulmonary septa, congested capillaries, alveolar emphysema and small areas of atelectasis. Nanoparticles were observed in the cytoplasm of cells lining bronchioles, in the alveolar spaces as well as inside the membranous pneumocytes and in phagosomes of lung macrophages. Nanoparticles even penetrated through the membrane into some organelles including mitochondria and they also accumulated in the cytoplasmic vesicles. In livers, inhalation caused periportal inflammation and local hepatic necrosis. Only minor changes such as diffusely thickened filtration membrane with intramembranous electron dense deposits were observed in kidney. Taken together, inhaled CdO nanoparticles not only accumulated in lungs but they were also transported to other organs causing serious damage at tissue as well as cellular level.
Workplace	Institute of Animal Physiology and Genetics
Contact	Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
Year of Publishing	2017

Number of the records: 1