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Photoluminescent polysaccharide-coated germanium(IV) oxide nanoparticles

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    SYSNO ASEP0460527
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitlePhotoluminescent polysaccharide-coated germanium(IV) oxide nanoparticles
    Author(s) Lobaz, Volodymyr (UMCH-V) RID, ORCID
    Rabyk, Mariia (UMCH-V) RID, ORCID
    Pánek, Jiří (UMCH-V) RID, ORCID
    Doris, E. (FR)
    Nallet, F. (FR)
    Štěpánek, Petr (UMCH-V) RID, ORCID
    Hrubý, Martin (UMCH-V) RID, ORCID
    Source TitleColloid and Polymer Science - ISSN 0303-402X
    Roč. 294, č. 7 (2016), s. 1225-1235
    Number of pages11 s.
    Languageeng - English
    CountryDE - Germany
    Keywordsgermanium oxide nanoparticles ; polysaccharide coating ; photoluminescent label
    Subject RIVCD - Macromolecular Chemistry
    R&D Projects7AMB14FR027 GA MŠk - Ministry of Education, Youth and Sports (MEYS)
    GA13-08336S GA ČR - Czech Science Foundation (CSF)
    NV15-25781A GA MZd - Ministry of Health (MZ)
    Institutional supportUMCH-V - RVO:61389013
    UT WOS000378567100013
    EID SCOPUS84969930665
    DOI10.1007/s00396-016-3882-y
    AnnotationIn current biomedically oriented research, the development of a biomimetic nanoparticle platform is of interest to provide a molecular toolbox (i.e., allowing easy modular exchange of its parts depending on actual needs while being nontoxic and allowing real-time recognition and tracking using various methods, such as fluorescence). We report the development of germanium(IV) oxide-polysaccharide composite particles possessing these properties. The nanoparticles are based on a crystalline germanium oxide core with a size range of 20–30 and 300–900 nm. Two new simple coating techniques were compared for the preparation of the photoluminescent polysaccharide-coated germanium(IV) oxide nanoparticles. The germanium(IV)-based core allows for in situ polysaccharide attachment via direct chelation. In addition, the nanoparticles were coated with thin layer of silicon oxide. After coating, 3-(triethoxysilyl)propyl isocyanate was grafted onto the surface, and the polysaccharides were immobilized on the particle surface via a covalent urethane linkage, which allows for an even more stable polysaccharide coating than that obtained via chelation. This approach provides access to a new material platform for biological track and image applications.
    WorkplaceInstitute of Macromolecular Chemistry
    ContactEva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
    Year of Publishing2017
Number of the records: 1