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Photoluminescent polysaccharide-coated germanium(IV) oxide nanoparticles

SYSNO ASEP	0460527
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Photoluminescent polysaccharide-coated germanium(IV) oxide nanoparticles
Author(s)	Lobaz, Volodymyr (UMCH-V)_{RID, ORCID} Rabyk, Mariia (UMCH-V)_{RID, ORCID} Pánek, Jiří (UMCH-V)_{RID, ORCID} Doris, E. (FR) Nallet, F. (FR) Štěpánek, Petr (UMCH-V)_{RID, ORCID} Hrubý, Martin (UMCH-V)_{RID, ORCID}
Source Title	Colloid and Polymer Science - ISSN 0303-402X Roč. 294, č. 7 (2016), s. 1225-1235
Number of pages	11 s.
Language	eng - English
Country	DE - Germany
Keywords	germanium oxide nanoparticles ; polysaccharide coating ; photoluminescent label
Subject RIV	CD - Macromolecular Chemistry
R&D Projects	7AMB14FR027 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA13-08336S GA ČR - Czech Science Foundation (CSF)
	NV15-25781A GA MZd - Ministry of Health (MZ)
Institutional support	UMCH-V - RVO:61389013
UT WOS	000378567100013
EID SCOPUS	84969930665
DOI	10.1007/s00396-016-3882-y
Annotation	In current biomedically oriented research, the development of a biomimetic nanoparticle platform is of interest to provide a molecular toolbox (i.e., allowing easy modular exchange of its parts depending on actual needs while being nontoxic and allowing real-time recognition and tracking using various methods, such as fluorescence). We report the development of germanium(IV) oxide-polysaccharide composite particles possessing these properties. The nanoparticles are based on a crystalline germanium oxide core with a size range of 20–30 and 300–900 nm. Two new simple coating techniques were compared for the preparation of the photoluminescent polysaccharide-coated germanium(IV) oxide nanoparticles. The germanium(IV)-based core allows for in situ polysaccharide attachment via direct chelation. In addition, the nanoparticles were coated with thin layer of silicon oxide. After coating, 3-(triethoxysilyl)propyl isocyanate was grafted onto the surface, and the polysaccharides were immobilized on the particle surface via a covalent urethane linkage, which allows for an even more stable polysaccharide coating than that obtained via chelation. This approach provides access to a new material platform for biological track and image applications.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2017

Number of the records: 1