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Electrochemical Methods for Determination of Three Tumor Biomarkers for Neuroblastoma: Homovanillic Acid, Vanillylmandelic Acid, and 5-Hydroxyindoleacetic Acid
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SYSNO ASEP 0459734 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Electrochemical Methods for Determination of Three Tumor Biomarkers for Neuroblastoma: Homovanillic Acid, Vanillylmandelic Acid, and 5-Hydroxyindoleacetic Acid Author(s) Makrlíková, A. (CZ)
Ktena, A. (GR)
Fischer, J. (CZ)
Navrátil, Tomáš (UFCH-W) RID, ORCID
Vyskočil, V. (CZ)Source Title XXXVI. Moderní elektrochemické metody. Sborník přednášek. - Ústí nad Labem : Best servis, 2016 / Navrátil T. ; Fojta M. ; Schwarzová K. - ISBN 978-80-905221-4-5 Pages s. 135-138 Number of pages 4 s. Publication form Print - P Action Moderní elektrochemické metody /36./ Event date 23.05.2016 - 27.05.2016 VEvent location Jetřichovice Country CZ - Czech Republic Event type WRD Language eng - English Country CZ - Czech Republic Keywords Screen-printed carbon electrodes ; Differential pulse voltammetry ; Homovanillic acid Subject RIV CG - Electrochemistry Institutional support UFCH-W - RVO:61388955 UT WOS 000389898200031 Annotation Tumor biomarkers – homovanillic acid, vanillylmandelic acid, and 5-hydroxyindoleacetic acid – have been determined at a screen-printed carbon electrode in small volume samples. For all measurements, Britton-Robinson buffer (0.04 moll−1, pH 3.0) was used as an optimum medium for all three analytes. Dependences of the peak current on the concentration were linear for all compounds, with the limits of quantification 0.8 μmol∙l–1 for homovanillic acid, 0.2 μmol∙l–1 for vanillylmandelic acid, and 0.2 μmol∙l–1 for 5-hydroxyindoleacetic acid. Depending on the results of the measurements, the future experiments should be performed in human urine. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2017
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