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The Regulatory Role of Nuclear Factor Kappa B in the Heart of Hereditary Hypertriglyceridemic Rat

SYSNO ASEP	0459551
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The Regulatory Role of Nuclear Factor Kappa B in the Heart of Hereditary Hypertriglyceridemic Rat
Author(s)	Vranková, S. (SK) Barta, A. (SK) Klimentová, J. (SK) Dovinová, I. (SK) Líšková, Silvia (FGU-C) Dobešová, Zdenka (FGU-C) Pecháňová, O. (SK) Kuneš, Jaroslav (FGU-C)_{RID, ORCID} Zicha, Josef (FGU-C)_{RID, ORCID, SAI}
Source Title	Oxidative Medicine and Cellular Longevity. - : Hindawi - ISSN 1942-0900 Roč. 2016, č. 2016 (2016), s. 9814038
Number of pages	6 s.
Language	eng - English
Country	US - United States
Keywords	nuclear factor-kB ; nitric oxide ; reactive oxygen species ; heart ; hereditary hypertriglyceridemic rats
Subject RIV	FA - Cardiovascular Diseases incl. Cardiotharic Surgery
R&D Projects	NV15-25396A GA MZd - Ministry of Health (MZ)
Institutional support	FGU-C - RVO:67985823
UT WOS	000377049600001
EID SCOPUS	84966283976
DOI	10.1155/2016/9814038
Annotation	Activation of nuclear factor-kB by increased production of reactive oxygen species (ROS) might induce expression of different antioxidant enzymes and nitric oxide synthase (NOS) isoforms. NF-kB inhibition in hereditary hypertriglyceridemic rats led to decreased ROS degradation by superoxide dismutase and to increased cardiac oxidative damage and elevated blood pressure. Under these conditions increased NO generation may represent a counterregulatory mechanism activate by ROS.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2017

Number of the records: 1