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Molecular-level control of ciclopirox olamine release from poly(ethylene oxide)-based mucoadhesive buccal films: exploration of structure–property relationships with solid-state NMR
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SYSNO ASEP 0459119 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Molecular-level control of ciclopirox olamine release from poly(ethylene oxide)-based mucoadhesive buccal films: exploration of structure–property relationships with solid-state NMR Author(s) Urbanová, Martina (UMCH-V) RID, ORCID
Gajdosova, M. (CZ)
Steinhart, Miloš (UMCH-V) RID
Vetchy, D. (CZ)
Brus, Jiří (UMCH-V) RID, ORCIDSource Title Molecular Pharmaceutics. - : American Chemical Society - ISSN 1543-8384
Roč. 13, č. 5 (2016), s. 1551-1563Number of pages 13 s. Language eng - English Country US - United States Keywords mucoadhesive buccal films ; ciclopirox olamine ; PEO Subject RIV CD - Macromolecular Chemistry R&D Projects GA14-03636S GA ČR - Czech Science Foundation (CSF) LO1507 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UMCH-V - RVO:61389013 UT WOS 000375519600012 EID SCOPUS 84968677705 DOI 10.1021/acs.molpharmaceut.6b00035 Annotation Mucoadhesive buccal films (MBFs) provide an innovative way to facilitate the efficient site-specific delivery of active compounds while simultaneously separating the lesions from the environment of the oral cavity. The structural diversity of these complex multicomponent and mostly multiphase systems as well as an experimental strategy for their structural characterization at molecular scale with atomic resolution were demonstrated using MBFs of ciclopirox olamine (CPX) in a poly(ethylene oxide) (PEO) matrix as a case study. A detailed description of each component of the CPX/PEO films was followed by an analysis of the relationships between each component and the physicochemical properties of the MBFs. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2017
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