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Variability of salivary markers of oxidative stress and antioxidant status in young healthy individuals
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SYSNO ASEP 0459052 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Variability of salivary markers of oxidative stress and antioxidant status in young healthy individuals Author(s) Lettrichová, I. (SK)
Tóthová, L. (SK)
Hodosy, J. (SK)
Behuliak, Michal (FGU-C) RID, ORCID
Celec, P. (SK)Source Title Redox Report. - : Taylor & Francis - ISSN 1351-0002
Roč. 21, č. 1 (2016), s. 24-30Number of pages 7 s. Language eng - English Country GB - United Kingdom Keywords biomarkers of oxidative stress ; carbonyl stress ; sex difference Subject RIV FP - Other Medical Disciplines Institutional support FGU-C - RVO:67985823 UT WOS 000373311900004 EID SCOPUS 84978758144 DOI 10.1179/1351000215Y.0000000009 Annotation Salivary advanced glycation end-products (AGEs), advanced oxidation protein products (AOPP), total antioxidant capacity (TAC), and ferric reducing ability of saliva (FRAS) are increased in various diseases. Little data exist for these markers in the healthy population. The aim of this study was to assess the inter-individual and intra-individual variability of AGEs, AOPP, TAC, and FRAS in the saliva of young healthy individuals. Unstimulated saliva samples were collected from 16 females and 18 males daily over a period of 30 days. Markers were measured using spectrophotometric and spectrofluorometric microplate-based methods. All salivary markers measured were significantly higher in men than in women (P < 0.05 for AGEs; P < 0.001 for AOPP, TAC, and FRAS). The inter-individual variability was approximately 60% for AGEs and AOPP and 30–40% for TAC and FRAS in both genders. The inter-individual variability of FRAS was higher in men vs. women (P < 0.01). Intra-individual variability ranged from 20% for TAC, to 30% for AGES and FRAS and 45% for AOPP. Intra-individual variability of salivary AGEs, AOPP, TAC, and FRAS indicates that their use is currently limited to large cohort studies. Identifying the underlying factors related to the high inter-individual and intra-individual variability is needed. Sex differences should be considered in future studies. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2017
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