Number of the records: 1
Alpha-glucosidase inhibitory and antiplasmodial properties of terpenoids from the leaves of Buddleja saligna Willd
- 1.
SYSNO ASEP 0458543 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Alpha-glucosidase inhibitory and antiplasmodial properties of terpenoids from the leaves of Buddleja saligna Willd Author(s) Chukwujekwu, J. C. (ZA)
Rengasamy, K.R.R. (ZA)
de Kock, C. A. (ZA)
Smith, P. J. (ZA)
Poštová Slavětínská, Lenka (UOCHB-X) RID
van Staden, J. (ZA)Source Title Journal of Enzyme Inhibition and Medicinal Chemistry. - : Taylor & Francis - ISSN 1475-6366
Roč. 31, č. 1 (2016), s. 63-66Number of pages 4 s. Language eng - English Country GB - United Kingdom Keywords alpha-glucosidase ; antidiabetic ; antiplasmodial ; Buddleja saligna ; terpenoids Subject RIV CC - Organic Chemistry Institutional support UOCHB-X - RVO:61388963 UT WOS 000367555300007 EID SCOPUS 84953292273 DOI 10.3109/14756366.2014.1003927 Annotation In our continuing search for biologically active natural product(s) of plant origin, Buddleja saligna, a South African medicinal plant, was screened in line with its traditional use for antidiabetic (yeast alpha glucosidase inhibitory) and antiplasmodial (against a chloroquine sensitive strain of Plasmodium falciparum (NF54)) activities. The hexane fraction showed the most promising activity with regards to its antidiabetic (IC50=260 +/- 0.112 mu g/ml) and antiplasmodial (IC50=8.5 +/- 1.6 mu g/ml) activities. Using activity guided fractionation three known terpenoids (betulonic acid, betulone and spinasterol) were isolated from this species for the first time. The compounds displayed varying levels of biological activities (antidiabetic: 27.31 mu g/ml >= C-50 >= 5.6 mu g/ml; antiplasmodial: 14 mu g/ml >= C-50 >= 2 mu g/ml) with very minimal toxicity. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2017
Number of the records: 1