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Moderate Changes in the Circadian System of Alzheimer's Disease Patients Detected in Their Home Environment

SYSNO ASEP	0458404
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Moderate Changes in the Circadian System of Alzheimer's Disease Patients Detected in Their Home Environment
Author(s)	Weissová, Kamila (FGU-C) Bartoš, A. (CZ) Sládek, Martin (FGU-C)_{RID, ORCID, SAI} Nováková, Marta (FGU-C) Sumová, Alena (FGU-C)_{RID, ORCID}
Source Title	PLoS ONE. - : Public Library of Science - ISSN 1932-6203 Roč. 11, č. 1 (2016), e0146200
Number of pages	19 s.
Language	eng - English
Country	US - United States
Keywords	circadian ; melatonin ; clock gene ; Alzheimer's disease
Subject RIV	FH - Neurology
R&D Projects	GBP304/12/G069 GA ČR - Czech Science Foundation (CSF)
Institutional support	FGU-C - RVO:67985823
UT WOS	000367681500067
EID SCOPUS	84954050120
DOI	10.1371/journal.pone.0146200
Annotation	Alzheimer's disease (AD) is a neurodegenerative disease often accompanied with disruption of sleep-wake cycle. The sleep-wake cycle is controlled by mechanisms involving internal timekeeping (circadian) regulation. The aim of our present pilot study was to assess the circadian system in patients with mild form of AD in their home environment. In the study, 13 elderly AD patients and 13 age-matched healthy control subjects (the patient's spouses) were enrolled. Sleep was recorded for 21 days by sleep diaries in all participants and checked by actigraphy in 4 of the AD patient/control couples. The samples of saliva and buccal mucosa were collected every 4 hours during the same 24 h-interval to detect melatonin and clock gene (PER1 and BMAL1) mRNA levels, respectively. The AD patients exhibited significantly longer inactivity interval during the 24 h and significantly higher number of daytime naps than controls. Daily profiles of melatonin levels exhibited circadian rhythms in both groups. Compared with controls, decline in amplitude of the melatonin rhythm in AD patients was not significant, however, in AD patients more melatonin profiles were dampened or had atypical waveforms. The clock genes PER1 and BMAL1 were expressed rhythmically with high amplitudes in both groups and no significant differences in phases between both groups were detected. Our results suggest moderate differences in functional state of the circadian system in patients with mild form of AD compared with healthy controls which are present in conditions of their home dwelling.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2017

Number of the records: 1