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Hematopoiesis in 5-Fluorouracil-Treated Adenosine A(3) Receptor Knock-Out Mice

SYSNO ASEP	0457632
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Hematopoiesis in 5-Fluorouracil-Treated Adenosine A(3) Receptor Knock-Out Mice
Author(s)	Hofer, Michal (BFU-R)_{RID, ORCID} Pospíšil, Milan (BFU-R) Dušek, L. (CZ) Hoferová, Zuzana (BFU-R)_RID Komůrková, Denisa (BFU-R)_{RID, ORCID}
Number of authors	5
Source Title	Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408 Roč. 64, č. 2 (2015), s. 255-262
Number of pages	8 s.
Publication form	Print - P
Language	eng - English
Country	CZ - Czech Republic
Keywords	Adenosine A(3) receptor knock-out mice ; Hematopoiesis ; 5-fluorouracil-induced hematotoxicity
Subject RIV	BO - Biophysics
Institutional support	BFU-R - RVO:68081707
UT WOS	000357409400013
Annotation	The purpose of the study was to describe and compare normal and 5-fluorouracil (5-FU)-suppressed hematopoiesis in adenosine A(3) receptor knock-out (A(3)AR KO) mice and their wild-type (WT) counterparts. To meet the purpose, a complex hematological analysis comprising nineteen peripheral blood and bone marrow parameters was performed in the mice. Defects previously observed in the peripheral blood erythrocyte and thrombocyte parameters of the A3AR KO mice were confirmed. Compartments of the bone marrow progenitor cells for granulocytes/macrophages and erythrocytes were enhanced in the control, as well as in the 5-FU-administered A3AR KO mice. 5-FU-induced hematopoietic suppression, evaluated on day 2 after the administration of the cytotoxic drug, was found to be significantly deeper in the A3AR KO mice compared with their WT counterparts, as measured at the level of the bone marrow progenitor cells. The rate of regeneration, as assessed between days 2 and 7 after 5-FU administration, was observed in the population of the granulocyte/macrophage progenitor cells to be higher in the A3AR KO mice in comparison with the WT ones.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2016

Number of the records: 1